{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:13:22Z","timestamp":1788365602177,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT2Is) are recommended in Japan for patients with cardiovascular disease (CVD), heart failure (HF), or chronic kidney disease (CKD) due to their organ\u2010protective effects, leading to increased use in high\u2010risk populations. However, whether urinary tract infection (UTI) risk associated with SGLT2Is differs according to the presence of these factors remains unclear. This study aimed to estimate UTI risk among SGLT2I users and treatment selection factors and examine whether these factors modify risk. We selected dipeptidyl peptidase\u20104 inhibitors (DPP4Is) as the comparators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used DeSC claims data from patients with diabetes mellitus who received their first prescription for either an SGLT2I or a DPP4I between October 2014 and February 2023. The analysis focused on data from 2019 to 2022. Hazard ratios (HRs) for UTI incidence were estimated using Cox proportional hazard regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 66,968 SGLT2I users and 170,678 DPP4I users were aged 65\u2009years or older. UTI incidence among SGLT2I users was 2.04% in those with treatment selection factors and 0.84% in those without. Compared with DPP4I users, the HR for UTI was 0.80 in patients with treatment selection factors and 0.51 in those without treatment selection factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SGLT2I use was not associated with an increase in UTI risk, regardless of treatment selection factor status. These findings suggest a favorable safety profile for SGLT2Is even among high\u2010risk populations, supporting their use following clinical guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70362","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:44:52Z","timestamp":1782135892000},"page":"1489-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Do the treatment selection factors emphasized in clinical guidelines\u2014Chronic kidney disease, cardiovascular disease, and heart failure\u2014contribute to the risk of urinary tract infections during the administration of sodium\u2010glucose cotransporter\u20102 inhibitors?"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6338-7396","authenticated-orcid":false,"given":"Takuma","family":"Koinuma","sequence":"first","affiliation":[{"name":"Department of Public Health and Epidemiology Meiji Pharmaceutical University  Tokyo Japan"},{"name":"Center for Experiential Pharmacy Practice, Faculty of Pharmacy Tokyo University of Pharmacy and Life Sciences  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manato","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology Meiji Pharmaceutical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4112-6035","authenticated-orcid":false,"given":"Manabu","family":"Akazawa","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology Meiji Pharmaceutical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106524"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.01.034"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.10.019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-019-00415-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1515920"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-020-00471-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.4511"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13960"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15472"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-084526"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2021.12.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ23-0317"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-3136"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06735-y"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13636"},{"key":"e_1_2_10_18_1","first-page":"466","article-title":"Trends in diabetes medication prescriptions: A 10\u2010year review by specialists","volume":"39","author":"Hosokawa C","year":"2022","journal-title":"Pract Diabetes"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0486-y"},{"key":"e_1_2_10_20_1","first-page":"190","article-title":"Prevalence of non\u2010communicable diseases in Japan using a newly developed administrative claims database covering young, middle\u2010aged, and elderly individuals","volume":"5","author":"Okada A","year":"2022","journal-title":"JMA J"},{"key":"e_1_2_10_21_1","unstructured":"Ministry of Health Labor and Welfare. 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