{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:13:25Z","timestamp":1788365605655,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy associated with substantial maternal and neonatal morbidity. Asian populations demonstrate increased susceptibility to glucose intolerance and may develop gestational diabetes earlier in pregnancy. However, the prevalence and outcomes of early\u2010diagnosed gestational diabetes mellitus (E\u2010GDM) in Asian populations remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was conducted following PRISMA guidelines. PubMed, ScienceDirect, and Web of Science were searched from database inception to February 2026 to identify studies evaluating gestational diabetes diagnosed before 24\u2009weeks of gestation in Asian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2329 records were identified, and 17 studies were included, with 16 eligible studies for meta\u2010analysis. E\u2010GDM prevalence ranged from 0.75% to 22.81%, accounting for 9.43%\u201378.78% of total GDM cases. Compared with conventional GDM, E\u2010GDM was associated with increased risks of C\u2010section or instrumental delivery (OR\u2009=\u20091.13, 95% CI 1.01\u20131.26), preterm birth (OR\u2009=\u20091.38, 95% CI 1.07\u20131.78), and insulin therapy requirement (OR\u2009=\u20091.60, 95% CI 1.09\u20132.36). Most neonatal outcomes were similar between groups. Women with E\u2010GDM showed greater metabolic vulnerability and possible postpartum metabolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>E\u2010GDM in Asian populations identifies women with greater metabolic vulnerability and increased obstetric risk. E\u2010GDM was associated with higher insulin requirements, increased risks of preterm birth and operative delivery, and possible long\u2010term metabolic dysfunction. Harmonized diagnostic criteria and region\u2010specific screening strategies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70381","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:59:44Z","timestamp":1783144784000},"page":"1591-1603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early diagnosis of gestational diabetes mellitus evidence from Asia countries: A meta\u2010analysis and systematic review"],"prefix":"10.1111","volume":"17","author":[{"given":"Ke Thi Lan","family":"Anh","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine Hai Phong University of Medicine and Pharmacy  Hai Phong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Ngoc","family":"Anh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine Hai Phong 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