{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:13:25Z","timestamp":1788365605198,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2025CXB030"],"award-info":[{"award-number":["2025CXB030"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders in pregnancy and is associated with significant maternal and fetal risks. The study aims to investigate lipid metabolism profiles associated with GDM to identify independent risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data from 17,452 women with singleton pregnancies who received regular prenatal care and nutritional assessment at Fujian Maternity and Child Health Hospital between December 2011 and December 2019 were analyzed. Participants were divided into GDM and control groups based on diagnosis. Gestational age was confirmed by first\u2010trimester ultrasound, and lipid profiles were measured in early (10\u201313\u2009weeks) and late pregnancy (28\u201332\u2009weeks). GDM was diagnosed using either a two\u2010step approach (2011\u20132014) or the International Association of Diabetes and Pregnancy Study Groups (IADPSG) one\u2010step 75\u2010g oral glucose tolerance test. Maternal characteristics, pregnancy outcomes, and lipid indicators\u2014including total cholesterol (TC), triglycerides (TG), LDL\u2010C, HDL\u2010C, and apolipoproteins (Apo\u2010A1, Apo\u2010B)\u2014were extracted. Feature selection was performed using LASSO regression and the Boruta algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age, TG\/HDL\u2010C ratio, TG, pre\u2010pregnancy BMI, and HDL\u2010C were identified as independent risk factors for GDM. Levels of ALT, HGB, Apo\u2010B, TC, TG, and TG\/HDL\u2010C ratio were significantly higher in the GDM group, while HDL\u2010C was lower (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Threshold analysis indicated that first\u2010trimester HDL\u2010C and TG\/HDL\u2010C ratio critical cut\u2010off points were 2.37 and 1.33, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Abnormal lipid metabolism is a hallmark of GDM and may serve as a predictive biomarker. Assessment of TG\/HDL\u2010C ratio and HDL\u2010C in early pregnancy could improve risk stratification and facilitate early interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70382","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:13:15Z","timestamp":1783696395000},"page":"1604-1616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipid metabolism profiles as predictors of gestational diabetes mellitus risk: A retrospective study"],"prefix":"10.1111","volume":"17","author":[{"given":"Xiaoyan","family":"Xiu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huale","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Health Care Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical 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