{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:00:59Z","timestamp":1792551659732,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the prevalence, risk factors, estimated glomerular filtration rate trajectory, and clinical implications of the early estimated glomerular filtration rate dip after sodium\u2010glucose cotransporter 2 inhibitors in a real\u2010world population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 1,550 patients who received sodium\u2010glucose cotransporter 2 inhibitor treatment at a single teaching hospital between 2014 and 2024. Patients were stratified into three groups based on early estimated glomerular filtration rate decline within the first 3\u2009months of treatment: non\u2010, moderate, and severe dippers (&lt;10%, 10%\u201330%, and \u226530%, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An early estimated glomerular filtration rate dip occurred in 21% of the patients; 17.6% were moderate dippers, and 3.5% were severe dippers. The risk factors for dipper classification included older age, atrial fibrillation, loop diuretic use, and high estimated glomerular filtration rate variability. Although the estimated glomerular filtration rate slopes declined progressively across dipper groups, the mean annual decline did not exceed age\u2010expected changes even in the severe dipper group. Patients who discontinued sodium\u2010glucose cotransporter 2 inhibitor therapy experienced a steeper decline than those who continued therapy. Three patients in the severe dipper group on concomitant loop diuretics experienced extreme estimated glomerular filtration rate reductions, which persisted during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early dips and continued sodium\u2010glucose cotransporter 2 inhibitor use are not generally associated with unfavorable outcomes. However, caution is warranted in frail or volume\u2010sensitive patients, particularly with concomitant diuretics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70410","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:22:17Z","timestamp":1785766937000},"page":"1735-1743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world risk factors and clinical implications of early estimated glomerular filtration rate decline after sodium\u2010glucose cotransporter\u20102 inhibitor therapy"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-5850","authenticated-orcid":false,"given":"Jangwook","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Dongguk University Ilsan Hospital, University of Dongguk College of Medicine  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4405-1592","authenticated-orcid":false,"given":"Dayoung","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicine Dongguk University Graduate School  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-830X","authenticated-orcid":false,"given":"Kyoung\u2010Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Dongguk University Ilsan Hospital, University of Dongguk College of Medicine  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6506-4342","authenticated-orcid":false,"given":"Han Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Dongguk University Ilsan Hospital, University of Dongguk College of Medicine  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4167-9028","authenticated-orcid":false,"given":"Soomin","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Medicine Dongguk University Graduate School  Seoul Korea"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Dongguk University Ilsan Hospital  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6111-208X","authenticated-orcid":false,"given":"Joeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Dongguk University Ilsan Hospital, University of Dongguk College of Medicine  Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae 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