{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T13:30:32Z","timestamp":1793626232285,"version":"4.5.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008092","name":"Jinhua Science and Technology Bureau","doi-asserted-by":"publisher","award":["2024\u20104\u2010239"],"award-info":[{"award-number":["2024\u20104\u2010239"]}],"id":[{"id":"10.13039\/501100008092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>This study aimed to elucidate the correlation between \u03b22\u2010microglobulin (\u03b22\u2010MG) and peripheral neuropathy in type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Diabetic peripheral neuropathy (DPN) was defined on the nerve conduction study (NCS). The general information and relevant clinical data of patients with T2DM were retrospectively analyzed using logistic regression to identify independent risk factors. The discriminative ability of individual and combined risk factors was evaluated using the area under the receiver operating characteristic curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1,219 patients with T2DM who received medical care at Dongyang People's Hospital between January 2023 and December 2023 were included in this study. Of the 954 patients with abnormal NCS findings, 899 exhibited sensory abnormalities, whereas 492 exhibited motor abnormalities. Multivariate analysis showed that DPN was positively correlated with age (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), \u03b22\u2010MG (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.022), uric acid (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.028), and male sex (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), but negatively correlated with albumin (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The combined discriminative power of these risk factors was 0.754, with \u03b22\u2010MG showing the highest individual diagnostic performance (AUC\u2009=\u20090.710).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>T2DM patients with advanced age, elevated \u03b22\u2010MG and uric acid levels, and hypoalbuminemia have higher DPN possibilities; follow\u2010up confirmation with NCS may facilitate the early diagnosis and management of peripheral neuropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70413","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:20:43Z","timestamp":1786425643000},"page":"1978-1985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Close relationship between \u03b22\u2010microglobulin and type 2 diabetes\u2010associated peripheral neuropathy"],"prefix":"10.1111","volume":"17","author":[{"given":"Jingfang","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Electromyography Dongyang People's Hospital  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Dongyang People's Hospital  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Dongyang People's Hospital  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3118-8278","authenticated-orcid":false,"given":"Panruo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Dongyang People's Hospital  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(24)00250-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8103904","article-title":"Gene expression profiling identifies downregulation of the neurotrophin\u2010MAPK signaling pathway in female diabetic peripheral neuropathy patients","volume":"2017","author":"Luo L","year":"2017","journal-title":"J Diabetes Res"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2042"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2020.0068"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3310\/RXUO6757"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3679"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1510053"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20171028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0727-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-S011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i23.8205"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1117-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000001372"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5918218"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158045"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1451"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59562-z"},{"key":"e_1_2_10_20_1","first-page":"732","article-title":"Peripheral neuropathy: Evaluation and differential diagnosis","volume":"102","author":"Gregory C","year":"2020","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26052105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16431"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401875"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13010"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.63219"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031031"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9123-1"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.534372"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3702"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70447"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.70413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T13:00:52Z","timestamp":1793624452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/jdi.70413"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70413","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"2026-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}