{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:55:00Z","timestamp":1790848500152,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The purpose of the study was to evaluate the accuracy, safety, and usability of a real\u2010time Continuous Glucose Monitoring (CGM) system compared with venous blood glucose (vBG) in children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study enrolled 81 participants aged from 3 to 17 at three sites in China. Two sensors (GS1, SiBionics, Shenzhen) were inserted on the back of each upper arm for up to 14\u2009days for each participant. A variety of analyses were conducted for evaluating accuracy by comparing the CGM readings and vBG values, including 20%\/20 agreement rate, the mean absolute relative difference (MARD), the Clarke error grid, and consensus error grid analyses. Safety was measured by adverse event (AE) monitoring. AEs were documented, and the incidence rate was calculated. Usability was evaluated by self\u2010reported questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 80 participants were analyzed. Our results demonstrated high accuracy of the real\u2010time CGM system. The 20%\/20 agreement rate across all glycemic ranges was 93.9%. The MARD value was 8.7%. The results of the Clarke and consensus error grid analyses in zone A\u2009+\u2009B were 99.6% and 100%, respectively. The average score of usability was 95.3\u2009\u00b1\u20097.6, reflecting high satisfaction. The CGM also showed high safety, given that only 3 device\u2010related AEs in 2 participants were reported\u00a0, and no serious adverse events (SAEs) were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The real\u2010time CGM system demonstrated high accuracy, safety, and usability in the glycemic monitoring of children and adolescents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.70415","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:45:30Z","timestamp":1786625130000},"page":"1807-1815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accuracy, safety, and usability of a real\u2010time continuous glucose monitoring system in pediatric diabetes management"],"prefix":"10.1111","volume":"17","author":[{"given":"Bingyan","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Endocrinology Children's Hospital Affiliated to Capital Institute of Pediatrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Genetics and Metabolism, Beijing Children's Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Hu","sequence":"additional","affiliation":[{"name":"Shenzhen SiBionics Co. Ltd  Shenzhen China"},{"name":"School of Biomedical Engineering Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingsong","family":"Han","sequence":"additional","affiliation":[{"name":"Shenzhen SiBionics Co. Ltd  Shenzhen China"},{"name":"Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School Tsinghua University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Genetics and Metabolism, Beijing Children's Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5835-8098","authenticated-orcid":false,"given":"Yifei","family":"Mo","sequence":"additional","affiliation":[{"name":"Shenzhen SiBionics Co. Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"IDF Diabetes Atlas","author":"Magliano D","year":"2021"},{"key":"e_1_2_10_3_1","first-page":"146","article-title":"Diabetes in childhood and adolescence","volume":"115","author":"Ziegler R","year":"2018","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14528"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2021.3073974"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2019.0121"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13029"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00319-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13410-022-01112-0"},{"key":"e_1_2_10_10_1","unstructured":"POCT05 | Performance Metrics for Continuous Interstitial Glucose Monitoring [Internet]. Clinical and Laboratory Standards Institute.https:\/\/clsi.org\/shop\/standards\/poct05\/."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.8.1143"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19976"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/19322968221091816"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6940"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1060"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1600"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521430"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S014"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13455"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296820958754"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110922"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2022.0513"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-024-03573-x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2012.05.007"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400502"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2023.0465"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.70415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.70415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:05:56Z","timestamp":1790845556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.70415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/jdi.70415"],"URL":"https:\/\/doi.org\/10.1111\/jdi.70415","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"2025-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}