{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:00:16Z","timestamp":1790240416266,"version":"4.1.0"},"reference-count":157,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Glycated albumin (GA), the product of nonenzymatic glycation of serum albumin, reflects the mean glucose levels over the preceding approximately 2\u2009weeks, bridging the gap between daily self\u2010monitoring of blood glucose and the roughly 3\u2010month window covered by glycated hemoglobin (HbA1c) measurement. First quantified in the early 1980s, GA was long overshadowed by HbA1c, but at present, interest has revived for two reasons. First, HbA1c assessment proves unreliable when the erythrocyte lifespan or hemoglobin glycation is perturbed, as in patients with renal failure, hemolytic anemia, hemoglobin variants, and iron deficiency. Second, continuous glucose monitoring has drawn attention to postprandial excursions and shortterm glucose variability that are not captured by HbA1c. This review revisits GA's biology, measurement, standardization, clinical utility, limitations, and evidence linking it to diabetic complications. Because it responds within 2\u2009weeks to treatment and is markedly influenced by postprandial glucose excursions, GA supports early monitoring of therapy, and its ratio to HbA1c serves as an index of postprandial glycemia and insulin secretion. However, it must also be recognized that conditions that alter albumin turnover change GA levels independently of blood glucose levels. The prognostic value of GA is strongest in patients on maintenance hemodialysis, although recent studies in various cohorts and a meta\u2010analysis have expanded situations in which GA measurement is of prognostic value. New measurement approaches, including finger\u2010prick sampling, weekly home measurement, and noninvasive saliva and tear assays, point toward a renewed role for GA measurement in everyday glucose monitoring in individuals with diabetes.<\/jats:p>","DOI":"10.1111\/jdi.70447","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:07:59Z","timestamp":1790237279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycated albumin: An old yet new biomarker in people with diabetes and the potential for novel applications"],"prefix":"10.1111","author":[{"given":"Masakazu","family":"Aihara","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine and Health Services Research David Geffen School of Medicine at UCLA  Los Angeles California 90024 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-2767","authenticated-orcid":false,"given":"Naoto","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Faculty of Life Sciences Kumamoto University  Kumamoto 860\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.2337\/diab.44.8.968","article-title":"The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial","volume":"44","author":"The DCCT Research Group","year":"1995","journal-title":"Diabetes"},{"key":"e_1_2_16_3_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1590\/2359-3997000000272","article-title":"Glycated albumin: A potential biomarker in 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