{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:47:27Z","timestamp":1776952047836,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>Both Oral PUVA and PUVA sol have been successfully used in vitiligo treatment. However, there is paucity of studies comparing the two therapies, especially under subtropical conditions of abundant sunlight where PUVA sol is more feasible.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold>To compare the efficacy and side effects of oral PUVA versus oral PUVA sol therapy in generalized vitiligo.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>Comparative prospective clinical trial conducted on consecutive patients of generalized vitiligo. Response to treatment was assessed using change in Lund &amp; Browder (L &amp; B) score for assessment of reduction in body surface area of involvement, patient global assessment (PGA) of improvement in vitiligo, investigator\u2019s global assessment (IGA) of extent of repigmentation, and quality of life (QOL) assessment using Tjioe et al questionnaire.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Thirty five patients were recruited\u2010 18 in PUVA and 17 in PUVA sol group. Mean percentage change in L &amp; B score at 36\u2003weeks was 46.4% in PUVA and 26.1% in PUVA sol group (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.06), mean PGA score in PUVA was 4.58\u2003\u00b1\u20032.23 and in PUVA sol group was 6\u2003\u00b1\u20032.08 (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.13), mean IGA score was 3.08\u2003\u00b1\u20031.68 in PUVA and 1.79\u2003\u00b1\u20030.57 in PUVA sol group (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.11). QOL scores were significantly higher in PUVA group as compared to the PUVA sol group (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.04). Side effects were comparable in two groups except for phototoxic side effects which were significantly more in PUVA group.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>PUVA is more efficacious than PUVA sol and also provides greater psychological benefit in treatment of generalized vitiligo but is associated with more phototoxic adverse effects.<\/jats:p>","DOI":"10.1111\/jdv.12002","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T11:36:16Z","timestamp":1350387376000},"page":"1344-1351","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of efficacy and side\u2010effect profile of oral PUVA vs. oral PUVA sol in the treatment of vitiligo: a 36\u2010week prospective study"],"prefix":"10.1111","volume":"27","author":[{"given":"S.","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Khandpur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ramam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"l29","DOI":"10.1038\/jid.1953.36","article-title":"Clinical and experimental studies with 8\u2010methoxypsoralen in vitiligo","volume":"20","author":"Lerner AB","year":"1953","journal-title":"J Invest 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