{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:41:50Z","timestamp":1776422510558,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T00:00:00Z","timestamp":1350604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Allergic contact dermatitis is a frequent, often disabling disease caused by countless substances. Patch testing remains the gold standard test to identify the causative agent; however, it is subjective, time\u2010consuming and not completely safe. Alternative methods were tried, but significant success has only been achieved with nickel.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> Develop an alternative or complementary allergic contact dermatitis diagnostic test.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We compared the lymphocyte proliferative rate and cytokine production (IFN\u2010\u03b3, IL\u20102, IL\u20104, IL\u20105, IL\u201010, IL\u201012, IL\u201013, IL\u201017 and RANTES) between 18 chromium allergic patients and 19 controls.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The lymphocyte proliferation test and some of the cytokines tested (IFN\u2010\u03b3, IL\u20102, IL\u20105, IL\u201012 and IL\u201013) were able to discriminate allergic patients. However, striking results were only achieved using IL\u201013, leading to an accuracy of about 90%.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> If further studies confirm the data found, IL\u201013 could be used as an alternative or complementary test to detect chromium contact allergy whereas lymphocyte proliferation test, IFN\u2010\u03b3, IL\u20102, IL\u20105 and IL\u201012 detections may serve as additional diagnostic tests.<\/jats:p>","DOI":"10.1111\/jdv.12005","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T08:01:26Z","timestamp":1350633686000},"source":"Crossref","is-referenced-by-count":5,"title":["IL\u201013: a marker of chromium contact 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