{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:45:35Z","timestamp":1787877935602,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T00:00:00Z","timestamp":1350000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Topical immunotherapy has recently been found useful in the treatment of chronic and extensive Alopecia Areata (AA).<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate the efficacy and safety of diphenylcyclopropenone (DPCP) use among Chinese patients with steroid resistant and extensive AA in our institute.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The medical records of 31 Chinese patients treated with DPCP were analysed retrospectively. The efficacy, adverse effects, and relapse rate of DPCP treatment were reviewed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Thirty\u2010one (16 male, 15 female) Chinese patients with extensive, steroid resistant Alopecia Areata and a mean age of 28.9\u2003years (SE 10.4) were treated. The mean age of onset was 17.8\u2003years (SE 8.8) with an average disease duration of 11.2\u2003years (SE 7.7). Ten patients had a history of atopy and 4 had a history of thyroid disease. Nail changes were found in 14 patients and a family history of AA was found in 2 patients. Thirteen patients (41.9%) had experienced total hair loss. Two patients abandoned the treatment due to severe side effects. Of the remaining 29 patients, 4 (13.8%), 7 (24.1%), 5 (17.2%), and 13 (44.8%) achieved &gt;90% complete response, &gt;50\u201390% partial response, &gt;10\u201350% minimal response, and &lt;10% no response hair regrowth, respectively. Adverse effects included pruritus, erythema, vesiculation, scaling, cervical lymphadenopathy, dyspigmentation and urticarial reactions. Relapse occurred (&gt;25% hair loss) in 69.23% of patients after 18\u2003months of follow up.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> DPCP is an effective and tolerable treatment for Chinese patients with extensive, steroid resistant AA.<\/jats:p>","DOI":"10.1111\/jdv.12009","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T10:39:30Z","timestamp":1350038370000},"source":"Crossref","is-referenced-by-count":21,"title":["Efficacy and safety of diphenylcyclopropenone among Chinese patients with steroid resistant and extensive alopecia 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