{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:52:27Z","timestamp":1790229147633,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T00:00:00Z","timestamp":1351296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Hailey\u2010Hailey disease (HHD) or familial benign chronic pemphigus is a rare autosomal dominant inherited skin disorder, characterized by flaccid vesicles and erosions on the intertriginous areas. Current treatments are not particularly effective. We report 6 cases dramatically improving with doxycycline.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case reports\u2002<\/jats:bold>\n                    6 patients, aged from 33 to 77 years old, presented with a variable 4 to 40 year history of severe treatment\u2010resistant HHD. All 6 patients were then treated successfully with doxycycline 100 mg per day for at least 3 months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion\u2002<\/jats:bold>\n                    An improvement was observed in all 6 patients from 1 week to 3 months after the beginning of treatment. Relapses were observed after various periods. Maintenance half\u2010dose therapy seemed to be beneficial in patients experiencing recurrence. Only one patient developed gastro\u2010intestinal intolerance. No other side effects were reported. Currently, 2 patients have improved and present a decreased number of exacerbations, 2 others are in complete remission after more than 5 years of follow\u2010up. Treatment efficiency is difficult to evaluate in HHD as it is a rare condition. No controlled studies have been published. Local treatments may improve inflammation but do not treat the underlying cause, targeted systemic therapies exist but there is little evidence supporting their use, physical treatments are cumbersome. Besides their antibiotic potential, tetracycline antibiotics also have anti\u2010inflammatory properties and anticollagenase activity via inhibition of matrix metalloproteinases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2002<\/jats:bold>\n                    Doxycycline appears to be an interesting therapeutic option in Hailey\u2010Hailey disease.\n                  <\/jats:p>","DOI":"10.1111\/jdv.12016","type":"journal-article","created":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T03:33:49Z","timestamp":1351308829000},"page":"370-373","source":"Crossref","is-referenced-by-count":43,"title":["Familial benign chronic pemphigus and doxycycline: a review of 6 cases"],"prefix":"10.1111","volume":"28","author":[{"given":"L.","family":"Le Sach\u00e9\u2010de Peufeilhoux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Raynaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bouchardeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fraitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bodemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/71701"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05904.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.381"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00658.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1939.01480220064005"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700447"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410025462"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1950.01530170094014"},{"key":"e_1_2_5_10_2","first-page":"10","article-title":"A review on Hailey\u2010Hailey disease","volume":"15","author":"Cheng TS","year":"2007","journal-title":"Hong Kong J Dermatol Venereol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0791"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962010000500021"},{"key":"e_1_2_5_13_2","first-page":"33","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"21","author":"Sapadin AN","year":"2003","journal-title":"Clin Dermatol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08286.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.10.007"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246223"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700031"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.9.2109"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:29:48Z","timestamp":1696271388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,27]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/jdv.12016"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12016","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,27]]}}}