{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:26:31Z","timestamp":1769027191344,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:00:00Z","timestamp":1351036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Hypertrophic port\u2010wine stains (PWS) usually respond poorly to pulsed dye laser treatment. The long\u2010pulsed 1064\u2003nm Nd:YAG laser can target deeper situated vessels and may therefore be more effective.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate the efficacy and safety of the Nd:YAG laser for the treatment of hypertrophic PWS.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In a retrospective cohort study, all hypertrophic PWS patients treated with the Nd:YAG laser between 2005 and 2011 were invited for follow\u2010up. Clinical improvement was assessed using Physician Global Assessment (PhGA) and Patient Global Assessment (PGA).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Assessment was obtained in 32 of 44 eligible patients (mean age 51.4\u2003years), after a mean of 2.8 (SD\u2003\u00b1\u20032.1) Nd:YAG laser treatments. Good or excellent improvement of hypertrophy was found in a majority of patients, both by PhGA (91%) and PGA (93%). Good or excellent improvement of colour was found in 63% of patients by PhGA, and in 87% by PGA. Recurrence of hypertrophy was seen in three patients. All but two patients would recommend Nd:YAG treatment to other patients. Mild to moderate scars were seen in seven patients, hypopigmentation in 14 patients.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The 1064\u2003nm Nd:YAG laser is highly effective in the treatment of hypertrophic PWS with only a few treatments needed. Mostly mild side effects were seen in half of all patients. Hypertrophy seems to respond better than colour. To further improve colour, a combination with pulsed dye laser treatment is advisory. Observation of immediate clinical endpoints is important when using the Nd:YAG laser, to optimize outcomes and reduce side effects.<\/jats:p>","DOI":"10.1111\/jdv.12021","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T11:43:12Z","timestamp":1351078992000},"page":"1381-1386","source":"Crossref","is-referenced-by-count":29,"title":["Long\u2010pulsed 1064\u2003nm Nd:YAG laser improves hypertrophic port\u2010wine stains"],"prefix":"10.1111","volume":"27","author":[{"given":"A.M.","family":"van Drooge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bosveld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.W.","family":"van der Veen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"de 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