{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:42:29Z","timestamp":1778341349627,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lion\u2032s Cancer Research Foundation"},{"DOI":"10.13039\/501100004885","name":"Ume\u00e5 University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Cancer Society","award":["11 0651"],"award-info":[{"award-number":["11 0651"]}]},{"DOI":"10.13039\/501100002960","name":"V\u00e4sterbotten County Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002960","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The pathogenesis of oral lichen planus (OLP), a chronic inflammatory disease, is not fully understood. It is known that OLP has autoimmune features, and it is suggested to be an autoimmune disease. ELF\u20103 is involved in differentiation of keratinocytes and deregulated in different tumours and inflammatory diseases. CXCR\u20103 and its ligands CXCL\u201010 and CXCL\u201011 are increased in autoimmune diseases and linked to Th\u20101 immune response.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To analyse and compare expression of ELF\u20103, CXCR\u20103, CXCL\u201010 and CXCL\u201011 in OLP lesions and controls in whole and microdissected epithelium.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Tissue biopsies from 20 patients clinically and histologically diagnosed with OLP and 20 healthy controls were studied using whole tissues or microdissected epithelium. By the use of qRT\u2010PCR, mRNA levels of ELF\u20103, CXCR\u20103, CXCL\u201010 and CXCL\u201011 were studied. Western blot was used for analysis of ELF\u20103 protein expression. Sera from 19 OLP patients and 20 controls were analysed with ELISA in search for autoantibodies.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The upregulation of CXCR\u20103, CXCL\u201010 and CXCL\u201011 found in OLP is similar to previous findings showing an autoimmune phenotype in lichen planus (LP) and lichen sclerosus. Decreased expression of the differentiation\u2010related transcription factor ELF\u20103 was also seen in OLP lesions, and we further demonstrate presence of circulating autoantibodies against the ELF\u20103 protein in sera from 3 of 19 (16%) LP patients tested.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> On the basis of these findings, we confirm that OLP shows features of an autoimmune disease and suggest deregulated differentiation of keratinocytes to be one of the causes of the disease phenotype.<\/jats:p>","DOI":"10.1111\/jdv.12027","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T10:47:37Z","timestamp":1352371657000},"page":"1410-1416","source":"Crossref","is-referenced-by-count":11,"title":["Autoantibodies and decreased expression of the transcription factor ELF\u20103 together with increased chemokine pathways support an autoimmune phenotype and altered differentiation in lichen planus located in oral 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