{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:19:52Z","timestamp":1778746792934,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T00:00:00Z","timestamp":1354752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Beh\u00e7et\u2019s disease (BD) is a recurrent multisystemic inflammatory disease characterized by recurrent oral aphthous and genital ulcers, ocular lesions and cutaneous lesions. Although many studies of cytokine levels in sera of BD patients have been conducted, there are only limited number of studies about the cytokine expression and cellular infiltration in the BD\u2010related skin lesions.<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To investigate the immunophenotypes and cytokine profiles of BD\u2010related skin lesions.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Twenty patients who fulfilled the diagnostic criteria for BD with BD\u2010related skin lesions were enrolled in this study. We assessed the histopathological features of BD\u2010related skin lesions by immunohistochemical studies with anti\u2010human CD4, CD8, CD68, FoxP3, CD\u201011b, IFN\u2010\u03b3 and IL\u20104 antibodies.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Immunophenotyping of inflammatory infiltrating cells showed that CD68+ macrophages were the most common type of infiltrated cells in erythema nodosum\u2010like lesions, erythema multiforme\u2010like lesions and Sweet\u2019s syndrome\u2010like lesions, whereas neutrophils were the main population of inflammatory infiltrating cells in papulopustular lesions. In all of the four types of BD\u2010related skin lesions, the percentage of CD8+ T cells was higher than that of CD4+ T cells (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05), and IL\u20104 expression was stronger than IFN\u2010\u03b3 expression (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> In this study, we assessed the infiltrating inflammatory cells and cytokine expression of acute cutaneous lesions in BD through immunohistochemical staining of BD\u2010related skin lesions. Further studies about the disease activity and the molecular biology underlying the cutaneous inflammation are needed to understand the detailed pathogenesis of BD.<\/jats:p>","DOI":"10.1111\/jdv.12054","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T12:08:52Z","timestamp":1354795732000},"page":"51-57","source":"Crossref","is-referenced-by-count":15,"title":["Immunopathogenic characterization of cutaneous inflammation in Beh\u00e7et\u2019s disease"],"prefix":"10.1111","volume":"28","author":[{"given":"S.","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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