{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:27:36Z","timestamp":1788870456506,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Seoul National University Bundang Hospital Research Fund","award":["02-2011-040"],"award-info":[{"award-number":["02-2011-040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Indole\u20103\u2010acetic acid (IAA) is a newly introduced photosensitizer of photodynamic therapy (PDT) for acne, presenting sebum\u2010reducing, anti\u2010inflammatory and antimicrobial activity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    This study was designed to evaluate the efficacy and safety of IAA\u2010PDT in the treatment of facial seborrhoeic dermatitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method\u2002<\/jats:bold>\n                    In this prospective, single\u2010blinded, 6\u2010week trial, 23 patients with facial seborrhoeic dermatitis were treated with IAA\u2010PDT with green light (520\u2003nm) three times with 1\u2010week intervals. Patients were evaluated at baseline, week 1, 2, 3 and week 6 (3\u2003weeks after last treatment). Efficacy was determined by Seborrhoeic dermatitis Area and Severity Index (SASI), patient\u2019s assessment of the symptoms (4\u2010point scale of itchiness, burning, erythema, scale and tightness), sebum secretion rate (measured with Sebumeter\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ), Erythema Index (EI, measured with Mexameter\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ) and physician\u2019s photographic assessment. Safety was evaluated by questionnaire at each visit.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Result\u2002<\/jats:bold>\n                    For the 22 subjects completing the trial, SASI and total symptom significantly improved at week 2, which lasted until week 6. Sebum excretion was significantly reduced at week 2 and stayed reduced until week 6. EI presented continuous reduction throughout the study. Photographic assessment showed significant improvement at each visit. The procedure was painless, and no adverse event was observed during and after the treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    IAA\u2010PDT is a safe and effective therapeutic option for facial seborrhoeic dermatitis.\n                  <\/jats:p>","DOI":"10.1111\/jdv.12070","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T05:44:49Z","timestamp":1357796689000},"page":"94-99","source":"Crossref","is-referenced-by-count":29,"title":["A new therapeutic option for facial seborrhoeic dermatitis: indole\u20103\u2010acetic acid photodynamic therapy"],"prefix":"10.1111","volume":"28","author":[{"given":"S.H.","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Y.","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.C.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.W.","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.H.","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.I.","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1997.d01-231.x"},{"key":"e_1_2_6_3_2","first-page":"1","article-title":"Skin conditions and related need for medical care among persons 1\u201074\u2003years. 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