{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T12:47:59Z","timestamp":1774183679049,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma treatment modalities including topical and procedural therapy have been employed with variable results and high recurrence rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To quantitatively assess improvement in melasma and side effects after 1410\u00a0nm fractional photothermolysis laser treatments and to determine efficacy at 1\u2010, 2\u2010 and 3\u2010month follow\u2010up after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty volunteers with melasma were treated with 1410\u00a0nm fractional photothermolysis for four passes on full face and additional four passes on melasma area. They were randomly treated on one side of their face with 20\u00a0mJ at 5% coverage and the other side of their face with 20\u00a0mJ at 20% coverage. All subjects were treated monthly for five times. Melanin index, Visual analogue scale and Melasma Area and Severity Index score were measured at baseline and 1\u2010, 2\u2010 and 3\u2010month follow\u2010up after complete treatment protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was statistically significant improvement of Melanin index at 2\u2010 and 3\u2010month follow\u2010up visits, but not at 1\u2010month follow\u2010up visit. Visual analogue scale and Melasma Area and Severity Index score improved significantly on both sides at 1\u2010, 2\u2010 and 3\u2010month follow\u2010ups. The overall patients' satisfaction was significantly higher on the side treated with 20\u00a0mJ, 5% coverage. Adverse reactions included erythema, dryness and post\u2010inflammatory hyperpigmentation on melasma area. Those side effects were significantly more intense on the side treated with 20\u00a0mJ, 20% coverage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>1410\u00a0nm fractional photothermolysis laser treatment is a safe and temporary effective procedure for melasma; however, long\u2010term follow\u2010up is still needed. Only 5% coverage should be used to minimize risks of adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12100","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T16:22:56Z","timestamp":1359044576000},"page":"293-297","source":"Crossref","is-referenced-by-count":12,"title":["The efficacy in melasma treatment using a 1410\u00a0nm fractional photothermolysis laser"],"prefix":"10.1111","volume":"28","author":[{"given":"R.","family":"Wanitphakdeedecha","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Siriraj Hospital, Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Keoprasom","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Siriraj Hospital, Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Eimpunth","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Siriraj Hospital, Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Manuskiatti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine, Siriraj Hospital, Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1961.01580080114013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690240119022"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(89)90053-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70071-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.032074.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08103.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01066.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170310021797"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1994.tb03707.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1993.tb00360.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2310\/6350.2005.31302"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.34062.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2008.09.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(85)90145-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690060057005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.02.009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31922"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.33650"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20484"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12100","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:28:08Z","timestamp":1696285688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,24]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/jdv.12100"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12100","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,24]]}}}