{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:12:04Z","timestamp":1791994324584,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Society of Dermatology"},{"name":"German Association of Office-Based Dermatologists"},{"name":"Leo Pharma Germany"},{"name":"Almirall-Hermal, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In Europe, only few and inconsistent data on the prevalence and treatment of actinic keratoses (\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      ) are available.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To determine the prevalence of\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      in Germany, to identify potential predictors and to estimate the number of\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      cases treated in dermatological practices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a multiple\u2010source approach, prevalence was assessed from whole\u2010body examinations in a cohort of 90\u00a0800 employees and from nationwide statutory health insurance (\n                      <jats:styled-content style=\"fixed-case\">SHI<\/jats:styled-content>\n                      ) data of 2008. The number of cases documented in dermatological offices was estimated from statistics of a\n                      <jats:styled-content style=\"fixed-case\">SHI<\/jats:styled-content>\n                      Physicians Association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Standardized prevalence of\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      from dermatological examinations was 2.7%; the rate increased with age (11.5% in the group 60\u201370\u00a0years) and was higher for men (3.9%) than for women (1.5%). Significant associations were also identified for skin phototype I, sunburns in childhood and solar lentigines. Vitiligo and a history of melanoma were also, but not significantly, associated with\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      . In the\n                      <jats:styled-content style=\"fixed-case\">SHI<\/jats:styled-content>\n                      data analysis, standardized\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      prevalence was 1.8%. Age\u2010specific rates were below 1.5% up to 60\u00a0years and rose to 8.2% (13.2% in men) in the group 80\u201389\u00a0years. The prevalence from these large data sets \u2013 which is at the lower limit of studies from other countries \u2013 suggests about 1.7\u00a0million estimated\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      cases in Germany.\n                    <\/jats:p>\n                    <jats:p>\n                      In 2011,\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      accounted for 8.3% of the hundred most frequently treated dermatological outpatient diagnoses. The proportion of\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      cases has risen almost continuously over the last 10\u00a0years, compared to other dermatological conditions. Estimated annual number of\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      cases documented by dermatologists in Germany is about 1.7\u00a0million.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Actinic keratosis is a frequent condition in higher age groups and more prevalent in men; a relevant need for health care is evident. Predictors and risk factors for\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      are easy to identify in the population, which could also help to detect groups with special need for preventive measures.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.12102","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T11:22:48Z","timestamp":1359026568000},"page":"309-313","source":"Crossref","is-referenced-by-count":97,"title":["Prevalence and risk factors of actinic keratoses in Germany \u2013 analysis of multisource data"],"prefix":"10.1111","volume":"28","author":[{"given":"I.","family":"Schaefer","sequence":"first","affiliation":[{"name":"CVderm \u2013 German Center for Health Services Research in Dermatology, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Augustin","sequence":"additional","affiliation":[{"name":"CVderm \u2013 German Center for Health Services Research in Dermatology, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Spehr","sequence":"additional","affiliation":[{"name":"CVderm \u2013 German Center for Health Services Research in Dermatology, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Reusch","sequence":"additional","affiliation":[{"name":"CVderm \u2013 German Center for Health Services Research in Dermatology, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kornek","sequence":"additional","affiliation":[{"name":"CVderm \u2013 German Center for Health Services Research in Dermatology, University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08544.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03541.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.6.722"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0770"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10436.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000136656"},{"key":"e_1_2_5_8_1","unstructured":"KVNO. 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