{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:25:44Z","timestamp":1763036744788},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010grade anal intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content>) is currently considered a precursor of anal cancer. The population most susceptible to <jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content> is men who have sex with men (<jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>), especially if they are infected by <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We analysed the population diagnosed with <jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content> and evaluated anal cytology as a method of screening the at\u2010risk population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a retrospective review of patients diagnosed with <jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content> by means of a surgical biopsy between 2008 and 2010. We analysed the risk factors of the population affected and the degree of agreement with the cytology performed previously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period 41 patients were diagnosed with <jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content> and seven with anal canal carcinoma <jats:italic>in situ<\/jats:italic>; 77% were men, most <jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>. A history of receptive anal intercourse was found in 81% of the patients and in 71% there was an association with anogenital warts; 32 patients were <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive, most of them men. Of the patients with anal dysplasia of any type in the cytology, 90% had some grade of <jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content> or carcinoma <jats:italic>in situ<\/jats:italic> in the later biopsy. The degree of agreement between the cytology and the biopsy was 94% in the high\u2010grade dysplasias and 50% in the low\u2010grade dysplasias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anal cytology in at\u2010risk populations has a high degree of agreement with the biopsy when performed surgically, though less in low\u2010grade dysplasias, which must always be studied. More studies evaluating the degree of progression of <jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content> to anal cancer are necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12109","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T13:21:03Z","timestamp":1362489663000},"page":"658-661","source":"Crossref","is-referenced-by-count":7,"title":["Anal intraepithelial neoplasia in a sexually transmitted diseases outpatient clinic: correlation with cytological screening"],"prefix":"10.1111","volume":"28","author":[{"given":"J.B.","family":"Repiso Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Costa del Sol Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Frieyro\u2010Elicegui","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Costa del Sol Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Padilla\u2010Espa\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Costa del Sol Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Palma\u2010Carazo","sequence":"additional","affiliation":[{"name":"Service of General and Digestive Surgery Hospital Costa del Sol Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"de la Torre Lima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Costa del Sol Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Rivas\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Research support Unit Hospital Costa del Sol Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09712.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/488S10a"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09028-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70080-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-008-0013-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir064"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06737.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000199019.50451.a8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199704150-00004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e318207039a"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31821d6cb9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024946"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4994"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T10:35:50Z","timestamp":1696242950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/jdv.12109"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12109","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,5]]}}}