{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:18:12Z","timestamp":1783149492201,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A recent systematic evaluation of vitiligo and psoriasis comorbidity has not yet been reported in a large series of patients with vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the practical\/clinical implications in subjects with both vitiligo and psoriasis compared to those with vitiligo alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a case\u2010control study on 463 vitiligo patients in our clinic from March 2008 to April 2011. Medical assessment was performed by dermatologists using the modified Vitiligo European Task Force form.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In an univariate analysis, inflammation\/pruritus [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 2.42, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03], use of drugs that can induce psoriasis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.74, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), a family history (<jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>) of psoriasis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.87, <jats:italic>P<\/jats:italic> = 0.02), cardiovascular disease (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.70, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.7, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and type 2 diabetes mellitus (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.87, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), were significantly correlated with patients exhibiting vitiligo and psoriasis comorbidity. A trend was found in personal history of cardiovascular disease in patients with both diseases (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07). <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> of vitiligo was significantly associated with patients having only vitiligo (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.35, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05). Multivariate analysis demonstrated that inflammation\/pruritus in vitiligo macules (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.56, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.047) and a <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> of cardiovascular disease (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.07, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) were the most significant predictors of patients having both psoriasis and vitiligo, while the presence of organ\u2010specific autoantibodies (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.24, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) was significantly associated with patients having only vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of vitiligo and even mild psoriasis is significantly correlated with a family history of cardiovascular disease, a factor that requires greater attention and follow\u2010up with respect to that necessary for vitiligo patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12117","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T13:11:40Z","timestamp":1361884300000},"page":"433-437","source":"Crossref","is-referenced-by-count":23,"title":["Non\u2010segmental vitiligo and psoriasis comorbidity \u2013 a case\u2010control study in Italian patients"],"prefix":"10.1111","volume":"28","author":[{"given":"M.","family":"Arunachalam","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine and Surgery Division of Dermatology University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Dragoni","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Surgery Division of Dermatology University of Florence Florence 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