{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:02:18Z","timestamp":1791453738992,"version":"4.3.3"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic spontaneous urticaria (<jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content>) is a common skin disorder, which is considered in a subset of patients to be an autoimmune disorder. T helper 17 (Th17) cells are crucially involved in the pathogenesis of some autoimmune diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our aim was to test the association of Th17 with <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content>. We examined interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201017, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 and tumor necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) serum levels in <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content> patients and studied their association with urticaria activity and autologous serum skin test (<jats:styled-content style=\"fixed-case\">ASST<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>Serum concentration of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 were measured in 75 patients with <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content> and 30 healthy control subjects. Disease activity was assessed by using urticaria activity score (<jats:styled-content style=\"fixed-case\">UAS<\/jats:styled-content>) as recommended by <jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content><jats:sup>2<\/jats:sup><jats:styled-content style=\"fixed-case\">LEN<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">WAO<\/jats:styled-content> Guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum concentration of IL\u201017, IL\u201023 and TNF\u2010\u03b1 were significantly higher in CSU patients as compared with the healthy control subjects (mean: 35.51\u00a0\u00b1\u00a031.14 vs. 4.60\u00a0\u00b1\u00a01.38\u00a0pg\/mL; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001, 38.95\u00a0\u00b1\u00a027.82 vs. 9.87\u00a0\u00b1\u00a04.62\u00a0pg\/mL; <jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.001 and 17.93\u00a0\u00b1\u00a06.05 vs. 6.87\u00a0\u00b1\u00a03.73\u00a0pg\/mL; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.004, respectively). There were significant positive correlation between serum IL\u201017, IL\u201023, TNF\u2010\u03b1 and disease activity assessed by cumulative UAS for 7\u00a0days before blood sampling. The Serum concentration of IL\u201017, IL\u201023 and TNF\u2010\u03b1 were also significantly higher in ASST positive patients than in ASST negative patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results showed high serum levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 among <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content> patients which may highlight a functional role of these cytokines in the pathogenesis of this important and common skin disease. It also may provide the rationale for new treatment strategies in chronic urticaria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12124","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T18:24:05Z","timestamp":1362421445000},"page":"469-474","source":"Crossref","is-referenced-by-count":94,"title":["Serum concentration of <scp>IL<\/scp>\u201017, <scp>IL<\/scp>\u201023 and <scp>TNF<\/scp>\u2010\u03b1 among patients with chronic spontaneous urticaria: association with disease activity and autologous serum skin test"],"prefix":"10.1111","volume":"28","author":[{"given":"M.A.","family":"Atwa","sequence":"first","affiliation":[{"name":"Dermatology &amp; Venereology Department Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Emara","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.M.","family":"Bayoumy","sequence":"additional","affiliation":[{"name":"Physiology Department College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02496.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306033282204"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12338544"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118325"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70071-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115484"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02132.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02707.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01494.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90240-X"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.123236"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000066772"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01355"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041257"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030896"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207577200"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061308"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0407-345"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.004"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1497"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22866"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04754"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.12.5445"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90070-5"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.1.65"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0502-500"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00347.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2832"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00296-6"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.03.017"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.10.4220"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02179.x"},{"key":"e_1_2_5_35_1","unstructured":"Statistical package for Social Sciences Version 17 SPSS Inc. 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