{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:48:05Z","timestamp":1791917285444,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nail apparatus melanoma (<jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>) is a rare melanocytic neoplasm with pejorative prognosis often related to late diagnosis. Early diagnosis at <jats:italic>in situ<\/jats:italic> stage (<jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content><jats:italic>is<\/jats:italic>) is difficult, but essential to improve prognosis. <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content><jats:italic>is<\/jats:italic> management is not well established yet. Removal of the whole nail unit has been advocated in several small series as a potential treatment for <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content><jats:italic>is<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report and assess \u2018functional\u2019 or \u2018conservative\u2019 surgery for <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content><jats:italic>is<\/jats:italic> and evaluate its long\u2010term oncologic safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of cases diagnosed in the University Hospital Saint\u2010Pierre collected over a 13\u00a0year period and compared with the published data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven cases of <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content><jats:italic>is<\/jats:italic> were identified: 73% concerned females. Thumb and first toe were the most affected digits (63% of total). Monodactylic longitudinal melanonychia (<jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>) was the most frequent presentation (92%). Mean diagnosis delay was 5\u00a0years. Diagnosis was suspected on the basis of clinical and dermatoscopic signs and was confirmed by pathological examination. All patients underwent complete nail unit removal with 6\u00a0mm security margins around the anatomic boundaries of the nail. Two late local recurrences were observed at 7 and 11\u00a0years follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our series, the largest up to now, demonstrates that \u2018functional surgery\u2019 is a rational approach for <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content><jats:italic>is<\/jats:italic> with an excellent oncologic safety at 5\u00a0years. However, this study suggests that a very long\u2010term follow\u2010up is mandatory, as recurrences may appear late.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12131","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T05:38:24Z","timestamp":1363153104000},"page":"550-557","source":"Crossref","is-referenced-by-count":32,"title":["Management of <i>in situ<\/i> melanoma of the nail apparatus with functional surgery: report of 11 cases and review of the literature"],"prefix":"10.1111","volume":"28","author":[{"given":"F.","family":"Neczyporenko","sequence":"first","affiliation":[{"name":"Department of Dermatology Saint Pierre, Brugmann and Children's University Hospitals Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint Pierre, Brugmann and Children's University Hospitals Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Torosian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint Pierre, Brugmann and Children's University Hospitals Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Theunis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint Pierre, Brugmann and Children's University Hospitals Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"},{"name":"Department of Pathology Institut Bordet Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Richert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint Pierre, Brugmann and Children's University Hospitals Universit\u00e9 Libre de Bruxelles (ULB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,11]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"71","article-title":"Nail apparatus melanoma. 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