{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:59:42Z","timestamp":1767974382741,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000377","name":"Dunhill Medical Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) and neurological disease has been the subject of numerous recent studies and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> antigens and their isoforms have been identified in the central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>). Whilst epidemiological data support this association, little is known about the pathomechanism behind this link and the immunological characteristics of patients with BP and neurological disease, other than multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>), has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to compare the cutaneous immune response in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients with and without neurological disease, to investigate whether or not there is a distinctive immunopathological profile in patients with concomitant <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and neurological disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010two patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> were included and divided into two groups; those with neurological disease (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a043) and those without (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u2212<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a029). Patients in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content> group had a confirmed neurological disease by a hospital physician, neurologist or psychiatrist with positive neurological imaging where appropriate, or a <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>arnofsky score of 50 or less due to mental impairment. All sera were analysed with indirect immunofluorescence (<jats:styled-content style=\"fixed-case\">IIF<\/jats:styled-content>) using serial dilutions up to 1:120000, immunoblotting (<jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median antibody titres by <jats:styled-content style=\"fixed-case\">IIF<\/jats:styled-content> were 1:1600 vs. 1:800 for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u2212<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>, respectively, although the difference did not reach statistic significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.93, <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ann\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>hitney <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\u2010test). <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> values for both <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230 did not differ significantly between the two groups. Similarly, autoantibodies to specific antigens as identified by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> were not related to the presence of neurological disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study indicate that patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and neurological disease exhibit an immune response to both <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230, thus the link between the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> and the skin is not dependent on a specific antigen, but possibly both antigens or their isoforms may be exposed following a neurological insult, and play a role in generation of an immune response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12136","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T11:33:58Z","timestamp":1364297638000},"page":"569-573","source":"Crossref","is-referenced-by-count":27,"title":["Immunopathological characteristics of patients with bullous pemphigoid and neurological disease"],"prefix":"10.1111","volume":"28","author":[{"given":"K.","family":"Taghipour","sequence":"first","affiliation":[{"name":"Division of Genetics and Molecular Medicine King's College London UK"},{"name":"Department of Dermatology Oxford University Hospitals Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010C.","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chang Gung Memorial Hospital Chiayi Taiwan"},{"name":"College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bhogal","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology Immunodermatology laboratories St Thomas' Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.W.","family":"Groves","sequence":"additional","affiliation":[{"name":"Division of Genetics and Molecular Medicine King's College London UK"},{"name":"St John's Institute of Dermatology Immunodermatology laboratories St Thomas' Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Venning","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oxford University Hospitals Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Wojnarowska","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Medicine Oxford University Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.322"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.301"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.357"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10386.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.9936"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200012098"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1995.0003"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20549"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.012260"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2005.11.004"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.04.073"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1995.tb01375.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.01.037"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.032"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-7190-6_2"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8567"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315393"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12136","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T10:34:43Z","timestamp":1696242883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,26]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/jdv.12136"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12136","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,26]]}}}