{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:13:50Z","timestamp":1790730830805,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Frontal fibrosing alopecia (\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      ) is a primary lymphocytic cicatricial alopecia with characteristic clinical pattern of progressive frontotemporal hairline recession, perifollicular erythema and hyperkeratosis and symptoms of itch and burning, occurring mainly in post\u2010menopausal women.\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      is considered a subtype of lichen planopilaris (\n                      <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>\n                      ), based on their identical histopathology. Currently, no evidence\u2010based treatment is available for\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      . Our aim was to determine the effectiveness of available treatment options for\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      , and to identify promising treatment options for future studies. For this, literature search was conducted to find all primary studies on the treatment of\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>\n                      . From the primary studies, data were subtracted and analysed. No randomized controlled trials were found, and one controlled trial. Treatment of 114 patients is described in the literature. They received 10 different regimes, of which oral 5\u2010alpha\u2010reductase inhibitors were provided most often, resulting in good clinical response in 45% of them. Hydroxychloroquine resulted in good clinical response in 30% of the 29 treated patients. Topical corticosteroid preparations are ineffective in\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      . The remaining treatments were all reported in less than 10 patients. For the treatment of\n                      <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>\n                      , topical corticosteroid preparations are the first line of treatment, followed by oral cyclosporine and systemic corticosteroids, although they are characterized by a high relapse rate. Summarizing, there is currently no effective treatment of\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      , the most effective being oral 5\u2010alpha\u2010reductase inhibitors that possibly affect the accompanying androgenetic alopecia. We argue that oral cyclosporine A might be a good candidate for future studies on the treatment of\n                      <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.12139","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T07:33:59Z","timestamp":1364283239000},"page":"1461-1470","source":"Crossref","is-referenced-by-count":129,"title":["Treatment of frontal fibrosing alopecia and lichen planopilaris: a systematic review"],"prefix":"10.1111","volume":"27","author":[{"given":"E.","family":"R\u00e1cz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gho","sequence":"additional","affiliation":[{"name":"Hair Science Institute The 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