{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:07:08Z","timestamp":1787242028569,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Primary localized cutaneous amyloidosis (\n PLCA<\/jats:styled-content>\n ) is a chronic pruritic dermatological disorder of unknown aetiology. Genetic mutations in cases of familial\n PLCA<\/jats:styled-content>\n have been mapped to the oncostatin\u2010\n M<\/jats:styled-content>\n receptor (\n OSMR<\/jats:styled-content>\n ) \u03b2, a subunit of interleukin (\n IL<\/jats:styled-content>\n )\u201031 receptor.\n IL<\/jats:styled-content>\n \u201031 has been implicated in the pathogenesis of atopic dermatitis (\n AD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To assess if\n AD<\/jats:styled-content>\n is more prevalent in patients with\n PLCA<\/jats:styled-content>\n compared to patients with other conditions attending the same dermatology clinic. Secondarily, to investigate if the prevalence of\n AD<\/jats:styled-content>\n , severity of itch, morphology and locations of\n PLCA<\/jats:styled-content>\n differ between familial and sporadic forms.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Consecutive patients with the clinical diagnosis of\n PLCA<\/jats:styled-content>\n visiting a dermatology clinic were evaluated by a single investigator. Data on demographics, family history, morphological types and locations of\n PLCA<\/jats:styled-content>\n , and itch score were collected and they were screened for concomitant\n AD<\/jats:styled-content>\n based on history and physical examination. The control population consisted of consecutive patients with diagnoses other than\n PLCA<\/jats:styled-content>\n seen in the same clinic.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 44 patients with and 97 controls were evaluated. The prevalence of\n AD<\/jats:styled-content>\n in patients with\n PLCA<\/jats:styled-content>\n was significantly higher than in controls, at 75% and 39.2% respectively (\n OR<\/jats:styled-content>\n \u00a0=\u00a04.66, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a02.10 to 10.3, p\u00a0<\u00a00.0005). The prevalence of\n AD<\/jats:styled-content>\n in sporadic cases was significantly higher than familial cases, at 84.4% and 50% respectively (\n OR<\/jats:styled-content>\n \u00a0=\u00a05.4, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.23 to 23.7). Mean itch levels, morphological types and locations of\n PLCA<\/jats:styled-content>\n did not differ between familial and sporadic cases.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n AD<\/jats:styled-content>\n was associated with\n PLCA<\/jats:styled-content>\n and the association was stronger with the sporadic compared to the familial cases.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.12144","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T21:11:13Z","timestamp":1363209073000},"page":"810-813","source":"Crossref","is-referenced-by-count":18,"title":["Primary localized cutaneous amyloidosis: association with atopic dermatitis"],"prefix":"10.1111","volume":"28","author":[{"given":"B.","family":"Chia","sequence":"first","affiliation":[{"name":"Internal Medicine Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tan","sequence":"additional","affiliation":[{"name":"Annenberg School for Communication University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.L.","family":"Tey","sequence":"additional","affiliation":[{"name":"Dermatology National Skin Centre Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(90)90083-D"},{"key":"e_1_2_5_3_1","first-page":"101","article-title":"Clinical and histopathological characteristics of primary cutaneous amyloidosis in 794 Chinese patients","volume":"64","author":"Wang WJ","year":"2001","journal-title":"Zhonghua yi xue za zhi (Taipei)"},{"key":"e_1_2_5_4_1","first-page":"2627","volume-title":"Textbook of Dermatology","author":"Black MM","year":"1998"},{"key":"e_1_2_5_5_1","first-page":"1822","volume-title":"Cutaneous Medicine and Surgery","author":"Hashimoto K.","year":"1996"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70001-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.002"},{"issue":"1","key":"e_1_2_5_8_1","first-page":"71","article-title":"Galectin 7\u2010associated PLCA","volume":"17","author":"Westermark P","year":"2010","journal-title":"Amyloid"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23617"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70117-0"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb15003.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00109.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.16230"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10024.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.02941.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0867"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.033"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12144","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:30:48Z","timestamp":1695558648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,12]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/jdv.12144"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12144","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,12]]}}}