{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:18:51Z","timestamp":1792603131241,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,13]],"date-time":"2013-04-13T00:00:00Z","timestamp":1365811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with Gorlin syndrome develop multiple basal cell carcinomas (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>), for which treatment is often difficult. Methylaminolevulinate\u2010photodynamic therapy (<jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) is approved for the treatment of superficial and nodular <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>s in Canada and several European countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To establish consensus recommendations for the use of <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> in patients with Gorlin syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Gorlin consensus panel was comprised of 7 dermatologists who had treated a total of 83 patients with Gorlin syndrome using <jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. Consensus was developed based on the personal experience of the expert and results of literature review (on <jats:styled-content style=\"fixed-case\">PUBMED<\/jats:styled-content> using the keywords \u2018<jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2019 and \u2018<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>\u2019 and \u2018Gorlin\u2019 or \u2018naevoid basal cell carcinoma syndrome\u2019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Consensus was reached among the experts and the literature review identified 9 relevant reports. The experts considered MAL\u2010PDT a generally effective and safe therapy for treatment of BCC in Gorlin syndrome. For superficial BCC (<jats:styled-content style=\"fixed-case\">sBCC<\/jats:styled-content>), all sizes can be treated, and in nodular BCC (<jats:styled-content style=\"fixed-case\">nBCC<\/jats:styled-content>), better efficacy can be achieved in thinner lesions (&lt;2\u00a0mm in thickness). MAL\u2010PDT treatment schedule should be performed according to labelling although in individual cases, it may be adapted and performed on a monthly basis based on clinical assessment. Follow\u2010up should be related to frequency of recurrence, and severity, number and location of lesions. Multiple lesions and large areas may be treated during the same session; however, adequate pain management should be considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MAL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> is safe and effective in patients with Gorlin syndrome. Utilization of these recommendations may improve efficacy and clearance rates in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12150","type":"journal-article","created":{"date-parts":[[2013,4,13]],"date-time":"2013-04-13T07:04:37Z","timestamp":1365836677000},"page":"626-632","source":"Crossref","is-referenced-by-count":38,"title":["Consensus recommendations for the treatment of basal cell carcinomas in <scp>G<\/scp>orlin syndrome with topical methylaminolaevulinate\u2010photodynamic therapy"],"prefix":"10.1111","volume":"28","author":[{"given":"N.","family":"Basset\u2010Seguin","sequence":"first","affiliation":[{"name":"H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bissonnette","sequence":"additional","affiliation":[{"name":"Innovaderm Research Montreal 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