{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:33:52Z","timestamp":1789893232130,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Current standard of treatment of bullous pemphigoid (\n BP<\/jats:styled-content>\n ) is systemic oral corticosteroids (\n CS<\/jats:styled-content>\n ). However, significant iatrogenic morbidity and mortality is reported. Studies have shown that topical potent\n CS<\/jats:styled-content>\n is safer than oral prednisolone in\n BP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To examine the local and systemic efficacy and adverse effects of whole body clobetasol propionate cream application in patients with mild or severe\n BP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Open, clinical records\u2010based retrospective analysis of a series of mild (\n n\u00a0<\/jats:italic>\n =\u00a040) and severe (\n n\u00a0<\/jats:italic>\n =\u00a034)\n BP<\/jats:styled-content>\n patients, treated with ranging doses (20\u201340\u00a0g\/day) clobetasol propionate cream. For assessing systemic effects, we observed in selected cases eosinophil count and morning urine cortisol level.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients with mild\n BP<\/jats:styled-content>\n achieved in 90.0% disease control and in severe\n BP<\/jats:styled-content>\n in 73.5%. Complete remission was achieved in mild\n BP<\/jats:styled-content>\n in 64.1% (35.9% off therapy and 28.2% on therapy) vs. 41.2% in severe\n BP<\/jats:styled-content>\n (5.9% off therapy and 35.3% on therapy). Local adverse effects were mainly skin atrophy (14.9%) and purpura (5.4%). Systemic adverse effects were rare (\n n\u00a0<\/jats:italic>\n =\u00a03) and consisted of deep vein thrombosis, hypertrichosis and adrenocortical insufficiency. Systemic effect was witnessed by immediate drop of eosinophil count, and decrease in the morning urine cortisol in selected cases.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Topical whole body application of clobetasol propionate cream as monotherapy can be effective and safe in the induction phase of treatment in mild\n BP<\/jats:styled-content>\n and severe\n BP<\/jats:styled-content>\n . When relapse occurs adjuvant systemic medication is mandatory. Potent\n CS<\/jats:styled-content>\n works locally and systemically against\n BP<\/jats:styled-content>\n , at the price of significant local and less significant systemic adverse effects.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.12153","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T08:21:38Z","timestamp":1364977298000},"page":"712-718","source":"Crossref","is-referenced-by-count":21,"title":["Whole body application of a potent topical corticosteroid for bullous pemphigoid"],"prefix":"10.1111","volume":"28","author":[{"given":"J.B.","family":"Terra","sequence":"first","affiliation":[{"name":"Centre for Blistering Diseases Department of Dermatology University of Groningen University Medical Centre Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.J.B.","family":"Potze","sequence":"additional","affiliation":[{"name":"Centre for Blistering Diseases Department of Dermatology University of Groningen University Medical Centre Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Jonkman","sequence":"additional","affiliation":[{"name":"Centre for Blistering Diseases Department of Dermatology University of Groningen University Medical Centre Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.301"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690130050009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690200097021"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.032"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011592"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.7.903"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70058-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04835.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.412"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10531.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.12.048"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2010.534127"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12153","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:29:58Z","timestamp":1695558598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,3]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/jdv.12153"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12153","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718201191.793488102","asserted-by":"object"}]},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,3]]}}}