{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:46:43Z","timestamp":1774486003255,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T00:00:00Z","timestamp":1370304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammation, increased sebum production and <jats:italic>P. acnes<\/jats:italic> colonization are key factors in acne pathogenesis. Cosmetic formulations based on a combination of active compounds with <jats:italic>in vitro<\/jats:italic> proven anti\u2010inflammatory, sebum regulating and <jats:italic>P. acnes<\/jats:italic> reducing properties may therefore contribute to improve the clinical signs and associated burden of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To provide <jats:italic>in vivo<\/jats:italic> proof\u2010of\u2010concept, we performed a 9\u2010week, double\u2010blind, randomized, vehicle\u2010controlled study to assess the stand\u2010alone efficacy of a skin care formulation containing licochalcone A, <jats:sc>l<\/jats:sc>\u2010carnitine and 1,2\u2010decanediol in volunteers with mild to moderately severe acne (10\u201325 inflammatory lesions) involving the face.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>After enrolment followed by a 1\u2010week standardization of the cleansing procedure, 60 volunteers aged 14\u201340\u00a0years (40 women and 20 men, mean age 22.4\u00a0years) were randomized into two groups of 30 volunteers each, to apply either the active formulation or the vehicle twice daily on the face for 8\u00a0weeks. Reduction in the lesion count, <jats:italic>P. acnes<\/jats:italic> and sebum levels, stratum corneum hydration, Dermatology Life Quality Index (<jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>) and skin tolerability, assessed after 4 and 8\u00a0weeks were defined as outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to baseline, the active formulation group showed at the end of the study a reduction in the mean total lesions count and papular lesions, significant reduction in the pustules (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) and sebum levels (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01), marked reduction in <jats:italic>P. acnes<\/jats:italic> and improvement of <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>. No significant changes in the respective parameters were found in the vehicle group. At the end of the study, greater reduction in the total lesion count, papules and pustules, <jats:italic>P. acnes<\/jats:italic> colonization, sebum production and more pronounced improvement of life quality in the active formulation group compared to the vehicle were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results provide evidence for improved outcomes in result of the application of the active formulation compared to the vehicle from both physician's and patient's perspective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12168","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T10:33:47Z","timestamp":1370342027000},"page":"6-11","source":"Crossref","is-referenced-by-count":31,"title":["A double\u2010blind, randomized, vehicle\u2010controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe 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