{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:36:43Z","timestamp":1775687803152,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin blistering diseases due to autoantibodies are typically treated with high dose systemic corticosteroids and other conventional immunosuppressants. However, in severe cases, this treatment may not be sufficient to achieve disease control or contraindicated because of comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We describe 15 patients (pts.) with such diseases: 6 pts. with pemphigus vulgaris, 3 pts. with bullous pemphigoid, 3 pts. with mucous membrane pemphigoid (\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      ), one being anti\u2010laminin\u2010332\u2010\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content>\n                      332\u2010\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      ), 2 pts. with pemphigus foliaceus and 1 pt. with epidermolysis bullosa acquisita (\n                      <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>\n                      ). Patients were treated with a combination of protein A immunoadsorption (\n                      <jats:styled-content style=\"fixed-case\">PAIA<\/jats:styled-content>\n                      , 3\u201321 treatments) and rituximab (3\u20136 treatments) in addition to low dose conventional immunosuppression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients showed rapid clinical improvement starting within the first 4\u00a0weeks and decline of circulating autoantibody levels. Complete\/partial remission was 88%\/12% in pemphigus and 71%\/29% in subepidermal blistering diseases. Overall relapse rate was 13% with an average follow\u2010up of 22\u00a0months. In the\n                      <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content>\n                      332\u2010\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      pt. the\n                      <jats:styled-content style=\"fixed-case\">PAIA<\/jats:styled-content>\n                      \/rituximab treatment was stopped because of an oesophagus cancer considered as the paraneoplastic cause of the skin disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Combined treatment with\n                      <jats:styled-content style=\"fixed-case\">PAIA<\/jats:styled-content>\n                      and rituximab showed rapid and long\u2010lasting response, thereby allowing substantial reduction of dosage of concomitant immunosuppressive medication. We hereby confirm data from other investigators that\n                      <jats:styled-content style=\"fixed-case\">PAIA<\/jats:styled-content>\n                      \/rituximab treatment is a promising therapeutical modality for pemphigus, pemphigoids and\n                      <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>\n                      , characterized by a favourable ratio of beneficial efficacy and minimized long\u2010term adverse effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.12175","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T04:18:05Z","timestamp":1367986685000},"page":"771-780","source":"Crossref","is-referenced-by-count":56,"title":["Treatment of severe autoimmune blistering skin diseases with combination of protein A immunoadsorption and rituximab: a protocol without initial high dose or pulse steroid medication"],"prefix":"10.1111","volume":"28","author":[{"given":"M.","family":"Kolesnik","sequence":"first","affiliation":[{"name":"Clinic for Dermatology and Venereology Otto\u2010von\u2010Guericke\u2010University Magdeburg Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Otto\u2010von\u2010Guericke\u2010University Magdeburg Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Reinhold","sequence":"additional","affiliation":[{"name":"Institute for Molecular and Clinical Immunology Otto\u2010von\u2010Guericke\u2010University Magdeburg Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ambach","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology and Venereology Otto\u2010von\u2010Guericke\u2010University Magdeburg Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.U.","family":"Heim","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Otto\u2010von\u2010Guericke\u2010University Magdeburg Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Gollnick","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology and Venereology Otto\u2010von\u2010Guericke\u2010University Magdeburg Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bonnekoh","sequence":"additional","affiliation":[{"name":"Clinic for Dermatology and Venereology Otto\u2010von\u2010Guericke\u2010University Magdeburg Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12275497"},{"key":"e_1_2_5_3_1","first-page":"357","article-title":"Treatment of autoimmune blistering diseases","volume":"52","author":"Rico MJ","year":"1993","journal-title":"Cutis"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2011.01.017"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1610-0387.2011.07809.x","article-title":"Autoimmune bullous skin diseases. 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