{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T01:29:52Z","timestamp":1776389392291,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Keratinocyte acantholysis as a result of pathogenic Dsg3\u2010antibodies production by B cells leads to Pemphigus vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>). Vitamin D, through its participation in several immune modulatory functions including B cells apoptosis, Th2 cell differentiation, apoptotic enzyme regulation and Tregs functions, may be actively involved in the immune regulation of<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate Vitamin D status in<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>patients in comparison to controls in an attempt to determine its role in this autoimmune disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>technique, 25\u2010hydroxyvitamin D (25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>) was determined for 34 pemphigus vulgaris patients and 20 healthy volunteers. Phosphorus and parathormone were also determined in the patient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>was significantly lower in patients than controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). There was a statistically significant difference between both groups regarding suboptimal Vit. D levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>have significantly lower serum vitamin D levels in comparison to controls and that these low levels were not related to age,<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>or pattern of sun exposure. The associated Vitamin D insufficiency in patients with<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>may possibly exacerbate their disease through various immune related mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12179","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T10:38:46Z","timestamp":1368182326000},"page":"859-863","source":"Crossref","is-referenced-by-count":30,"title":["Estimation of vitamin D levels in patients with pemphigus vulgaris"],"prefix":"10.1111","volume":"28","author":[{"given":"M.H.M.","family":"EL\u2010Komy","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Samir","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Cairo University Cairo 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