{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:29:40Z","timestamp":1780921780057,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T00:00:00Z","timestamp":1372204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Both palmoplantar pustulosis (<jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content>) and pompholyx are clinically characterized by acute eruptions of vesicles or pustules on the palms or soles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to compare the expression of certain inflammatory mediator genes and proteins between patients with <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content> and pompholyx using skin tissue samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin biopsies obtained from lesional skin from patients with PPP (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>7) and pompholyx (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) were analysed by quantitative RT\u2010PCR to measure the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels of nine genes, including IL\u20104, IL\u20108, IL\u20109, IL\u201017, IL\u201022, IFN\u2010\u03b3, CCL\u201020, granzyme and perforin. For immunohistochemical analysis, 34 paraffin\u2010embedded skin specimens (PPP, <jats:italic>n<\/jats:italic>\u00a0=\u00a022; pompholyx, <jats:italic>n<\/jats:italic>\u00a0=\u00a012) were stained with anti\u2010IL\u20108, IL\u201017A, IL\u201022 and granzyme B antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of genes analysed, IL\u20108 and IL\u201017A <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression levels were significantly higher in the PPP group than the pompholyx group (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.012 in both), whereas the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of granzyme B was significantly higher in pompholyx when compared with PPP (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.004). Regarding the IL\u201017A immunohistochemical staining, tissue from the PPP lesions contained significantly more IL\u201017A<jats:sup>+<\/jats:sup> cells in both the epidermis and papillary dermis when compared with pompholyx (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001 and <jats:italic>P\u00a0<\/jats:italic>=\u00a00.019 respectively). Moreover, the intensity of the IL\u20108 immunoreactivity was also greater in the PPP skin lesions than the pompholyx tissue (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A, both are increased in <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content> tissue, may represent important immunologic mediators that help to differentiate this clinical entity from pompholyx. This study may provide useful clues in distinguishing <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content> from pompholyx, as well as helping to understand the pathogeneses of these two diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12203","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T17:28:41Z","timestamp":1372267721000},"page":"1559-1565","source":"Crossref","is-referenced-by-count":14,"title":["A comparison of inflammatory mediator expression between palmoplantar pustulosis and pompholyx"],"prefix":"10.1111","volume":"27","author":[{"given":"D.Y.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.G.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Environmental Medical Biology and Institute of Tropical Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Departement of Pathology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute Yonsei University College of 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