{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:30:07Z","timestamp":1792402207467,"version":"4.4.0"},"reference-count":77,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In recent years, significant progress has been made in the understanding of the pathophysiological mechanisms of acne and the role of\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    . With this review, the authors aim to provide an update on the current understanding of the role of\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    in the development of acne lesions and analysing the potential implications for future treatments. A total of 188 articles published between January 1980 and March 2013 were searched using key words such as acne,\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    , microbiology,\n                    <jats:italic>Corynebacterium acnes<\/jats:italic>\n                    ,\n                    <jats:italic>acne vulgaris<\/jats:italic>\n                    , pathogenesis, antibiotic, vaccination and a combination of those key words. From those articles, 77 were analysed in depth. Recent data confirm that\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity, keratinocytes and sebaceous glands of the pilosebaceous follicle and leads to the development of comedones. Furthermore, the profile of its different strains may differ between healthy subjects and acne patients. The better understanding of the role of\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    may allow for new perspectives in the treatment of acne. Novel therapies should target molecules implicated in the activation of innate immunity, including toll\u2010like receptors, protease\u2010activated receptors and topical antimicrobial peptides; the latter may be an alternative to topical antibiotics and thus a solution for limiting bacterial resistance induced by topical macrolides. Vaccines may also be promising. However, the most appropriate candidate remains to be selected.\n                  <\/jats:p>","DOI":"10.1111\/jdv.12224","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T07:11:54Z","timestamp":1375341114000},"page":"271-278","source":"Crossref","is-referenced-by-count":231,"title":["<i>Propionibacterium acnes<\/i>\n                    : an update on its role in the pathogenesis of acne"],"prefix":"10.1111","volume":"28","author":[{"given":"C.","family":"Beylot","sequence":"first","affiliation":[{"name":"Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Auffret","sequence":"additional","affiliation":[{"name":"Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Poli","sequence":"additional","affiliation":[{"name":"Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010P.","family":"Claudel","sequence":"additional","affiliation":[{"name":"Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010T.","family":"Leccia","sequence":"additional","affiliation":[{"name":"Clinique de Dermatologie CHU A Michallon Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"CH Intercommunal de Fr\u00e9jus \u2013 St Raphael Dermatologie \u2013 Infectiologie Fr\u00e9jus France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dreno","sequence":"additional","affiliation":[{"name":"H\u00f4tel Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100330"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04218.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171700"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2005.03.001"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.29219-0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10458.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2012.07.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.335"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03467.x"},{"key":"e_1_2_12_11_1","first-page":"803","article-title":"The microbial ecology of pilosebaceous units isolated from human skin","volume":"130","author":"Leeming JP","year":"1984","journal-title":"J Gen Microbiol"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.326-334.2005"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27788-0"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012277"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02219.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041480"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/322972"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.05.013"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2007.02.001"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02747.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10897.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12264715"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087011"},{"key":"e_1_2_12_24_1","first-page":"20","article-title":"The expression of toll\u2010like receptors in dermatological diseases and the therapeutic effect of current and newer topical toll\u2010like receptor modulators","volume":"3","author":"Valins W","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.3.1535"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06933.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23705.x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039155"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2006.00156.x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01569.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0019-2805.2004.01816.x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.12-0365"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1074-z"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2004.05762.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06530.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00626.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00891.x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.02.015"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12035"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2012.01525.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701188"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700213"},{"key":"e_1_2_12_43_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1128\/iai.22.2.523-529.1978","article-title":"Complement activation in acne vulgaris: in vitro studies with Propionibacterium acnes and Propionibacterium granulosum","volume":"22","author":"Webster GF","year":"1978","journal-title":"Infect Immun"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1979.tb05641.x"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.6641649.x"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.8486"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12321.x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04602.x"},{"key":"e_1_2_12_49_1","first-page":"468","article-title":"The microbial content and complement C3 cleaving capacity of comedones in acne vulgaris","volume":"68","author":"Leeming JP","year":"1988","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12460324"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.8.3158-3165.1995"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0774-5"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.281"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.7.2675-2687.2006"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12477026"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.46"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102180999"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-961811"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08959.x"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.8102"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00552.x"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01339.x"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.111"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.08.001"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.417"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022120"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.05.003"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23805.x"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.02.006"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.292"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12530860"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00406418"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00404321"},{"key":"e_1_2_12_74_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1128\/iai.49.1.116-121.1985","article-title":"Susceptibility of Propionibacterium acnes to killing and degradation by human neutrophils and monocytes in vitro","volume":"49","author":"Webster GF","year":"1985","journal-title":"Infect Immun"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb04899.x"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001551"},{"key":"e_1_2_12_77_1","first-page":"639","article-title":"Acne vaccines targeting Propionibacterium acnes","volume":"144","author":"Kao M","year":"2009","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014797"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:29:34Z","timestamp":1696271374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/jdv.12224"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12224","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}