{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:31:19Z","timestamp":1777901479068,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T00:00:00Z","timestamp":1375401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Rosacea is an inflammatory skin disease with a chronic course. This study aimed to investigate the risk of cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>) in rosacea patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The study included 60 rosacea patients and 50 age\u2010 and gender\u2010matched controls. Demographic data, medical history, presence of cardiovascular risk factors were recorded. Waist circumference, height, and weight were measured, and the body mass index was calculated for each participant. Laboratory investigations, including fasting blood glucose, C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), very low\u2010density lipoprotein, low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>), high\u2010density lipoprotein, total cholesterol, triglyceride, lipoprotein(a) were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 66% of the rosacea patients were female (mean age: 44.65\u00a0\u00b1\u00a012.9\u00a0years) and 66% of the controls were female (mean age: 42.3\u00a0\u00b1\u00a012.3\u00a0years). Median disease duration in the rosacea group was 36\u00a0months. High total cholesterol (&gt;200\u00a0mg\/dL), LDL (&gt;130\u00a0mg\/dL) and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (&gt;0.8\u00a0mg\/L) levels, a family history of premature <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>, and a history of smoking and alcohol consumption were significantly more common in the rosacea patients compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rosacea patients may have a high risk of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>. As such, we recommend close follow\u2010up of rosacea patients because of the increased risk of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>. The mechanism underlying this increased risk is unknown, and additional randomized and controlled studies are required for clarification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12234","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T13:59:12Z","timestamp":1375451952000},"page":"1165-1169","source":"Crossref","is-referenced-by-count":87,"title":["Rosacea and cardiovascular risk factors: a case control study"],"prefix":"10.1111","volume":"28","author":[{"given":"N.","family":"Duman","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ersoy Evans","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Atakan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.03.030"},{"key":"e_1_2_5_3_1","first-page":"703","volume-title":"Fitzpatric's Dermatology in General Medicine","author":"PelLe MT","year":"2008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2008.04.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.07.016"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp567"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04075.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.03.035"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.01.025"},{"key":"e_1_2_5_11_1","first-page":"694","article-title":"Why is rosacea considered to be an inflammatory disorder? 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