{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:49:26Z","timestamp":1776311366345,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic pruritus is an important distressing condition that is often refractory to treatment. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that occurs without an organic cause.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate the relationship between chronic pruritus of undetermined origin (<jats:styled-content style=\"fixed-case\">CPUO<\/jats:styled-content>) and IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty patients with chronic pruritus (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) of undetermined origin and fifty healthy control subjects without pruritus were included into the study. All of the participants were examined by a gastroenterologist for concomitant IBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of IBS was found higher in patients with CP of undetermined origin (<jats:italic>P<\/jats:italic>: 0.02), but we did not observe any significant association between pruritus intensity and either presence of IBS (<jats:italic>P<\/jats:italic>: 0.08) or the subtypes of the syndrome (<jats:italic>P<\/jats:italic>: 0.40). Furthermore, patients with CP of undetermined origin between 40 and 60\u00a0years, female gender and longer duration of the disease were found to be significantly associated with the presence of IBS (<jats:italic>P<\/jats:italic>: 0.02, <jats:italic>P<\/jats:italic>: 0.01 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that the frequency of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> was higher in patients with CP than in healthy controls. Our study is the first report about the relation between CP of undetermined origin and IBS. Further studies with larger numbers of the patients are needed to show association between <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CPUO<\/jats:styled-content> using laboratory tests to define underlying diseases such as lactose intolerance, functional dyspepsia and emotional diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12251","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T08:43:01Z","timestamp":1377592981000},"page":"1034-1039","source":"Crossref","is-referenced-by-count":8,"title":["Irritable bowel syndrome in patients with chronic pruritus of undetermined origin"],"prefix":"10.1111","volume":"28","author":[{"given":"\u00d6.","family":"Ekiz","sequence":"first","affiliation":[{"name":"Department of Dermatology Tayfur Ata Sokmen Medical School Mustafa Kemal University Hatay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130.","family":"Balta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ke\u00e7i\u00f6ren Training and Research Hospital Ankara"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"\u00d6zu\u011fuz","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Kocatepe University Afyon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.B.","family":"\u015een","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tayfur Ata Sokmen Medical School Mustafa Kemal University Hatay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.N.","family":"Rifaio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tayfur Ata Sokmen Medical School Mustafa Kemal University Hatay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ekiz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Antakya State Hospital Hatay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130.","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e.","family":"\u00c7oban","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6.","family":"Ba\u015far","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12570-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0305"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0662"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0320"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1400"},{"key":"e_1_2_5_7_1","first-page":"107","article-title":"Skin disease in Lambeth. 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