{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:57:42Z","timestamp":1792097862276,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiotherapy (RT) is one of the treatments of choice as skin\u2010directed therapy in Mycosis Fungoides (MF), both in first stages of the disease as total skin electron beam irradiation and in tumoural stage as localized treatment with conventional energies or electrons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Through a retrospective study, to evaluate the results of localized superficial RT in a series of 100 patients affected by MF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All the patients, after diagnosis supported by histological and immunophenotyping investigations, have been treated with conventional RT (range 50\u2013150\u00a0kV) and a total dose ranging from 9 to 40\u00a0Gy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete remission of the irradiated lesion has been observed in 88%, partial remission in 6% and non\u2010response in 2%. Four patients were lost to follow\u2010up. Local relapse has been observed in 13 lesions, with a local control rate of 85% after 5\u00a0years from the end of RT. Cosmetic results have been good and acceptable in 93% of cases. The treatment has been always well tolerated. The results confirm to be dose dependent, and show that better response is found in the range of higher energies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Localized RT is an effective and safe tool in the care and palliation of MF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12254","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T08:03:47Z","timestamp":1378195427000},"page":"1040-1044","source":"Crossref","is-referenced-by-count":8,"title":["Localized conventional radiotherapy in the treatment of Mycosis Fungoides: our experience in 100 patients"],"prefix":"10.1111","volume":"28","author":[{"given":"R.","family":"Piccinno","sequence":"first","affiliation":[{"name":"Servizio di Fotoradioterapia UO Dermatologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Caccialanza","sequence":"additional","affiliation":[{"name":"Servizio di Fotoradioterapia UO Dermatologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"\u00c7uka","sequence":"additional","affiliation":[{"name":"Servizio di Fotoradioterapia UO Dermatologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Recalcati","sequence":"additional","affiliation":[{"name":"Servizio di Fotoradioterapia UO Dermatologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq183"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22139"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08852.x"},{"key":"e_1_2_6_6_1","first-page":"1","volume-title":"Controversies in the Treatment of Skin Neoplasias","author":"Wilson LD","year":"2006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2007.02.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2012.02.007"},{"key":"e_1_2_6_9_1","first-page":"237","volume-title":"Statistics in medicine","author":"Colton T","year":"1974"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(83)90321-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00553-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00218-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630802516571"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01145-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.06.1918"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1684\/ejd.2010.1224","article-title":"Role of radiation therapy in mycosis fungoides refractory to systemic therapy","volume":"21","author":"Sanctis V","year":"2011","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02773-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.103529"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.98"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.01.023"},{"key":"e_1_2_6_21_1","unstructured":"Stanford University.A multicenter open\u2010label randomized Phase I\/II Study evaluating the safety and efficacy of Low\u2010dose (12 Gy) TSEBT+ Vorinostat versus low\u2010dose TSEBT monotherapy in Mycosis Fungoides. 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