{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:15:39Z","timestamp":1787944539114,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A great deal of research has addressed the elevation of C\u2010reactive protein (CRP) among psoriatic patients and the role of this marker in assessment of disease severity and progression. However, there are some discrepancies in this area. We sought to figure out the relationship between <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> values and disease severity as well as the changes in marker levels after treatment through an extensive literature review. Comparison between CRP levels in psoriatic patients and those in healthy or non\u2010psoriatic individuals was also another focus of this review. A thorough search in Pubmed and Embase was conducted for articles investigating different aspects of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> measurement in patients with psoriasis. Overall, 32 articles were found to meet our inclusion criteria. Of 28 studies comparing the <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> values in psoriatic patients with those of controls, 24 found a statistically significant difference. In addition, 12 out of 16 papers examining the association between disease severity and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> values noted significant results. With regard to <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> changes over the course of a treatment, all 15 studies addressing this issue revealed a significant decrease in marker levels. In conclusion, high <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels only for moderate and severe forms of disease might be inferred from the literature and there is no sufficient evidence suggesting a similar association for mild disease as well. Moreover, <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> may serve interchangeably with Psoriasis Area and Severity Index (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>) as a measure of disease severity in the case of untreated psoriatic patients who do not have disease related arthritis. For other patients, however, a careful clinical examination and <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> calculation still remain the mainstay of severity assessment.<\/jats:p>","DOI":"10.1111\/jdv.12257","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T07:52:14Z","timestamp":1378194734000},"page":"700-711","source":"Crossref","is-referenced-by-count":95,"title":["C\u2010reactive protein in psoriasis: a review of the literature"],"prefix":"10.1111","volume":"28","author":[{"given":"S.","family":"Beygi","sequence":"first","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"},{"name":"National Elite Foundation Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Lajevardi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Abedini","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"83","article-title":"Acute phase proteins in psoriasis","volume":"33","author":"Biljan D","year":"2009","journal-title":"Coll Antropol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02963.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08334.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.14.1735"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03947.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08628.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-6-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04131.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.1.96"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.8.731"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8308-0"},{"key":"e_1_2_7_15_1","unstructured":"WellsG SheaB O'connellDet\u00a0al. 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