{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:16:07Z","timestamp":1764332167613},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:00:00Z","timestamp":1378252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of Health","award":["RF-2010-2316524"],"award-info":[{"award-number":["RF-2010-2316524"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Audiological abnormalities seen in various autoimmune disorders raises the question of whether such abnormalities also exist in alopecia areata.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was performed to detect possible audiological abnormalities in Alopecia areata (AA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population consisted of 51 patients with AA and 51 healthy controls. Autoscopic and audiometric examinations of both ears were performed in patients and controls. Audiometric examinations were performed using a pure tone audiometer in a silent cabin. Pure tone thresholds were determined for each ear at frequencies of 250\u201316000\u00a0Hz for air conduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sensorineural hypoacusis was found in 28 patients with AA (54.9%). Six of these 28 patients showed unilateral minimal hearing loss (&gt;30\u00a0dB) at high frequencies only (4000\u201316\u00a0000\u00a0Hz), while 22 showed bilateral minimal hearing loss (&gt;30\u00a0dB) at high frequencies only (4000\u201316\u00a0000\u00a0Hz). Hypoacusis was observed in 13 control subjects (25.4%). Sensorineural hypoacusis was significantly more frequent in AA patients than controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Follicular melanocytes may be an important target in the autoimmune process of AA and AA may have an effect on hearing function by affecting the melanocytes in the inner ear. Therefore, there may be a relationship between sensorineural hearing loss and the autoimmune disease, AA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12259","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T13:28:38Z","timestamp":1378301318000},"page":"1045-1048","source":"Crossref","is-referenced-by-count":14,"title":["Audiological abnormalities in patients with alopecia areata"],"prefix":"10.1111","volume":"28","author":[{"given":"H.","family":"Ucak","sequence":"first","affiliation":[{"name":"Department of Dermatology Dicle University Faculty of Medicine Diyarbakir"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Soylu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Medipol University Faculty of Medicine Istanbul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Elazig Education and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Dermatology Elazig Education and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Cicek","sequence":"additional","affiliation":[{"name":"Department of Dermatology Firat University Faculty of Medicine Elazig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Erden","sequence":"additional","affiliation":[{"name":"Department of Dermatology Elazig Education and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Akyigit","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Elazig Education and Research Hospital Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/70.7.628"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01357.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00161.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.00215.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12874660"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1993.tb00584.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03605.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.02004.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70196-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/010503998420568"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.32710"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2008.0563"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1242\/dev.107.3.453","article-title":"Another role for melanocytes: Their importance for normal stria vascular is development in the mammalian inner ear","volume":"107","author":"Steel KP","year":"1989","journal-title":"Development"},{"key":"e_1_2_10_15_1","first-page":"127","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Halaban R","year":"2003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12260111"},{"key":"e_1_2_10_17_1","first-page":"836","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Ortonne JP","year":"2003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489209100782"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.183.4127.853"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01583.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.07.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.017"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12259","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:12:29Z","timestamp":1695553949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,4]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/jdv.12259"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12259","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,4]]}}}