{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:50:59Z","timestamp":1790639459253,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T00:00:00Z","timestamp":1379980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of acne scars remains a challenge to dermatologists. Multiple modalities have been employed with variable results and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the efficacy and adverse effects of a fractional radiofrequency microneedle system (<jats:styled-content style=\"fixed-case\">FRMS<\/jats:styled-content>) on acne scars in Asians at 1\u2010, 3\u2010 and 6\u2010month follow\u2010up visits after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty subjects with atrophic acne scars for more than 6\u00a0months were enrolled in the study. All volunteers were treated with a <jats:styled-content style=\"fixed-case\">FRMS<\/jats:styled-content> on affected areas. The subjects were treated for a total number of three treatment sessions at 1\u2010month intervals. Subjective assessments were obtained at baseline, 1, 3 and 6\u00a0months after the last treatment session by self\u2010evaluation and two blinded dermatologists. Objective evaluation using an ultraviolet A\u2010light video camera was also performed. In addition, pain scores, immediate reactions, healing times and other adverse effects were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six subjects with skin phototypes III\u2013V completed treatment protocol. The average mean scar age was 7\u00a0years (range: 0.5\u201315\u00a0years). At 6\u2010month follow\u2010up visit, the majority of the subjects (42.3%) reported a 26\u201350% improvement on their acne scars. Percent reduction in scar volume corresponded to clinical evaluation. Adverse reactions of the treatment included pain, immediate oedema\/erythema, minimal scabbing and transient pigmentary alteration on treated areas. The average pain score was 5.6 of 10. Worsening of skin texture or new scar formation was not observed in any subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional radiofrequency microneedle system is a safe and effective device for treating acne scars in Asians with minimal risk of downtime and adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12267","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:03:14Z","timestamp":1381539794000},"page":"1219-1225","source":"Crossref","is-referenced-by-count":64,"title":["The efficacy in treatment of facial atrophic acne scars in Asians with a fractional radiofrequency microneedle system"],"prefix":"10.1111","volume":"28","author":[{"given":"V.","family":"Vejjabhinanta","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok 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