{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:09:08Z","timestamp":1790287748098,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) in the ungual apparatus is a rare neoplasia. Although it is the most prevalent malignant tumour in this region, its diagnosis is often delayed because it is likened to benign or infectious processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Present a case of <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> with subungual location in a toe, and carry out a review of the literature in relation to the most important aspects of subungual <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in toes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe the case of a white woman aged 72, with <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> located in the pulp and in the distal area of the nail bed of the third toe, associated with subungual exostosis. The literature on <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in the subungual area of toes, in all its forms under clinical or histopathological presentation, is reviewed by means of a search involving Medline, PubMed, and Google Academic, from January 1994 to December 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 36 cases of subungual <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in toes were reported in the 18\u00a0years that were reviewed. The average age of cases reviewed was 58.92, and the male\u2010to\u2010female ratio was 2\u00a0:\u00a01. The most affected toe is the hallux, in 69.4% of cases. In 50% of cases, aetiology is unknown or indeterminate; in 22.3% of cases, aetiology is metastatic; and in 19.5% of cases, it is associated with human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>). In 58.2% of cases, partial or total resection of the distal phalanx was carried out, of the entire toe, or of the osseous ray of the foot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic tissue irritation caused by microtrauma associated with subungual exostosis is the most probable aetiology of the case presented.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12271","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:27:17Z","timestamp":1381544837000},"page":"1292-1297","source":"Crossref","is-referenced-by-count":9,"title":["Subungual squamous cell carcinoma and exostosis in third toe \u2013 case report and literature review"],"prefix":"10.1111","volume":"28","author":[{"given":"J.","family":"Valero","sequence":"first","affiliation":[{"name":"Department of Human Anatomy and Histology University of Zaragoza Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gallart","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology University of Zaragoza Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology University of Zaragoza Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Deus","sequence":"additional","affiliation":[{"name":"Department of Surgery, Obstetrics and Gynecology University of Zaragoza Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lahoz","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology University of Zaragoza Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"482","article-title":"Squamous cell carcinoma of the great toe","volume":"33","author":"Lewis J","year":"1994","journal-title":"J Foot Ankle Surg"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-65-2-134"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-80-10-548"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30095.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsurg.2008.05.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02845.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-89-8-435"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04725.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-84-1-39"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70159-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb06346.x"},{"key":"e_1_2_6_13_1","first-page":"149","article-title":"Epitelioma cuniculatum: presentaci\u00f3n de tres casos y revisi\u00f3n de la literatura","volume":"34","author":"Brice\u00f1o T","year":"1996","journal-title":"Derm Venez"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-2592(97)90009-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110079801900511"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-90-6-309"},{"key":"e_1_2_6_17_1","first-page":"89","article-title":"Met\u00e1stasis de carcinoma pulmonar en las falanges distales de dos dedos del pie. 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