{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:05:32Z","timestamp":1761581132236},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Several genes encoding different Th1 and Th2 cytokines may play crucial roles in host susceptibility to Condyloma acuminatum (CA<\/jats:styled-content>). Mannose\u2010binding lectin (MBL<\/jats:styled-content>) is a serum lectin that mediates complement activation, and it is a member of innate immune system. MBL<\/jats:styled-content> gene polymorphisms are considered to be associated with several infectious diseases.<\/jats:p><\/jats:sec>Objective<\/jats:title>In this study, we investigated the association between cytokines and MBL<\/jats:styled-content> gene polymorphisms with CA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty patients with CA<\/jats:styled-content> and 40 healthy controls were enrolled in this study. These patients had not responded to at least a therapy modality and all patients had recurrent lesions. Polymorphism of cytokine [Th1 cytokines; tumour necrosis factor\u2010\u03b1 and interferon (IFN)\u2010\u03b3, Th2 cytokine; IL<\/jats:styled-content>\u20106, T regulatory\/suppressor cytokines; IL<\/jats:styled-content>\u201010 and transforming growth factor\u2010\u03b2] genes studies were performed by Polymerase chain reaction sequence\u2010specific primers method and MBL<\/jats:styled-content> genotyping were studied by PCR<\/jats:styled-content>\u2010restriction fragment length polymorphism method.<\/jats:p><\/jats:sec>Results<\/jats:title>With the aid of agglomerative hierarchical cluster analysis, we categorized subjects into two main clusters (cluster 1; formed by the majority of patients with CA<\/jats:styled-content>, cluster 2; formed by the majority of healthy controls), which were found to have significantly different distributions of IL<\/jats:styled-content>\u20106 and MBL<\/jats:styled-content> genotypes. Frequencies of IL<\/jats:styled-content>\u20106 (\u2010174) G\/G (P<\/jats:italic>\u00a0<\u00a00.001) and MBL AA<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.001) polymorphisms were significantly greater in the cluster 1. In contrast, significantly lower frequencies of the IL<\/jats:styled-content>\u20106\u00a0G\/C (P<\/jats:italic>\u00a0=\u00a00.046) genotype and MBL AB<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.001) genotype were observed in cluster 1.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These results suggest that the IL<\/jats:styled-content>\u20106\u00a0G\/G and MBL AA<\/jats:styled-content> gene polymorphisms are potential risk factors and that the IL<\/jats:styled-content>\u20106\u00a0G\/C and MBL AB<\/jats:styled-content> polymorphisms are a protective factor for occurrence and recurrence of CA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12273","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:27:49Z","timestamp":1381544869000},"page":"1306-1312","source":"Crossref","is-referenced-by-count":4,"title":["Relationship between the interleukin\u20106\u2010174 gene and mannose\u2010binding lectin codon 54 gene 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