{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T10:18:21Z","timestamp":1777025901625,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperhidrosis affects up to 3% of the population and negatively affects patients' quality of life. Craniofacial hyperhidrosis is a common complaint which has been successfully treated with botulinum toxin B (Btx B) since 2004 at our hidrosis clinics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and clinical effect of Btx B in craniofacial hyperhidrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The dermatology life quality index (<jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>) was monitored before and after treatment in 38 patients with craniofacial hyperhidrosis. Sweating before and after treatment was monitored by measuring trans epidermal water loss and by collecting gravimetric data. Global Assessment of Therapy in a 5\u2010grade scale was captured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> scores were significantly improved at follow\u2010up 2\u20134\u00a0weeks posttreatment and sweating was significantly reduced. <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> scores before treatment were 13\u00a0\u00b1\u00a01 (mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) and posttreatment 5\u00a0\u00b1\u00a01 which was highly statistically significant (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Sweating before treatment monitored with trans epidermal water loss was 52\u00a0\u00b1\u00a031\u00a0g\/m<jats:sup>2<\/jats:sup>\/h which decreased to 18\u00a0\u00b1\u00a07\u00a0g\/m<jats:sup>2<\/jats:sup>\/h (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) posttreatment. Gravimetric data yielded a sweat rate of 0.07\u00a0\u00b1\u00a00.08\u00a0mg\/min at baseline, which consequently dropped to 0.02\u00a0\u00b1\u00a00.05\u00a0mg\/min (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) posttreatment. Regarding the Global Assessment of Therapy 87% of the patients were satisfied (score 4\u20135) with the treatment result. In a 2\u2010year follow\u2010up, 74% returned for further treatments after a median time of 5\u00a0months. Side\u2010effects were mild and most commonly reported was stiffness of the forehead and the eyebrows.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this prospective, uncontrolled study Btx B seems to be both a safe and effective treatment in craniofacial hyperhidrosis improving quality of life and reducing extreme sweating.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12278","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:56:42Z","timestamp":1381543002000},"page":"1313-1317","source":"Crossref","is-referenced-by-count":25,"title":["Botulinum toxin B in the treatment of craniofacial hyperhidrosis"],"prefix":"10.1111","volume":"28","author":[{"given":"M.","family":"Karlqvist","sequence":"first","affiliation":[{"name":"Department of Dermatology Uppsala University University Hospital"},{"name":"Centre for Research and Development County Council of G\u00e4vleborg Uppsala University University Hospital 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