{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:52:14Z","timestamp":1776829934361,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The long\u2010term results of keloid treatments remain poor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the long\u2010term efficacy of a technique combining surgical excision and immediate cryosurgery in patients with ear keloids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed between January 2001 and June 2011. All patients referred for treatment of an ear keloid and undergoing subsequent surgical excision followed by immediate freezing of the postoperative wound using cryosurgery were included. The primary end\u2010point was the number of patients who achieved major flattening of the keloid (defined as a reduction of more than 80% of the keloid) at the time of the study after a minimum follow\u2010up of 24\u00a0months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010six patients with a total of 97 keloids were included. Median follow\u2010up time after treatment was 43\u00a0months. \u2018Major\u2019 flattening was observed in 69 keloids (71%). Fifty\u2010six of these lesions (81%) were treated with one session and 13 (19%) required a second session after keloid recurrence. Fifteen lesions (15%) were considered \u2018treatment failure\u2019, including 11 keloids in eight patients who were lost to follow\u2010up and four keloids which achieved less than 30% reduction of their surface. Thirteen other keloids were evaluated as displaying significant or moderate improvement. Treatment side\u2010effects were partial amputation of the ear lobe in three patients with a very large keloid of the ear lobe and hypopigmentation in five patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitation<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of surgical excision and cryosurgery can be considered for the treatment of large ear keloids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12282","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:15:41Z","timestamp":1381544141000},"page":"1324-1331","source":"Crossref","is-referenced-by-count":26,"title":["Treatment of earlobe keloids by surgical excision and cryosurgery"],"prefix":"10.1111","volume":"28","author":[{"given":"N.","family":"Litrowski","sequence":"first","affiliation":[{"name":"Dermatology Department Inserm U905 Institute for Research and Innovation in Biomedicine Rouen University Hospital University of Normandy Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Boullie","sequence":"additional","affiliation":[{"name":"Dermatology Department Inserm U905 Institute for Research and Innovation in Biomedicine Rouen University Hospital University of Normandy Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dehesdin","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology\u2010Head and Neck Surgery Department Rouen University Hospital Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"De Barros","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology\u2010Head and Neck Surgery Department Rouen University Hospital Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Joly","sequence":"additional","affiliation":[{"name":"Dermatology Department Inserm U905 Institute for Research and Innovation in Biomedicine Rouen University Hospital University of Normandy Rouen France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1832","volume-title":"Hypertrophic scars and keloids","author":"Rook A","year":"1986"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04022.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120788"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.1999.3132"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.11.1429"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6474.1056"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(64)80040-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2005.00084.x"},{"key":"e_1_2_6_10_1","first-page":"1249","article-title":"Medical and surgical management of keloids: a review","volume":"9","author":"Shockman S","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.02111.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.05.055"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.05.007"},{"key":"e_1_2_6_14_1","first-page":"591","article-title":"The treatment of hypertrophic scars and keloids","volume":"8","author":"Berman B","year":"1998","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680300074011"},{"key":"e_1_2_6_16_1","first-page":"45","volume-title":"Cryosurgery for Skin Cancer and Cutaneous Disorders","author":"Lubritz RR","year":"1985"},{"key":"e_1_2_6_17_1","first-page":"91","volume-title":"Cryosurgery for Skin Cancer and Cutaneous Disorders","author":"Glazer SF","year":"1985"},{"key":"e_1_2_6_18_1","first-page":"872","article-title":"Unsere Erfahrungen mit konservativen Therapiemethoden bei hypertrophen Narben und Keloiden","volume":"38","author":"Sebastian G","year":"1990","journal-title":"Dtsch Dermatol"},{"key":"e_1_2_6_19_1","first-page":"466","article-title":"Cryosurgery in dermatology","volume":"8","author":"Zouboulis CC","year":"1998","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198801000-00007"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04092.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(06)70884-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2310\/6350.2005.31321"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03911.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12282","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:24:36Z","timestamp":1695565476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,3]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/jdv.12282"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12282","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,3]]}}}