{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:16:47Z","timestamp":1790363807266,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T00:00:00Z","timestamp":1383782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shandong Province Higher Educational Science and Technology Program of China","award":["J10LF90"],"award-info":[{"award-number":["J10LF90"]}]},{"name":"Shandong Province Natural Science Foundation of China","award":["ZR2010HQ013"],"award-info":[{"award-number":["ZR2010HQ013"]}]},{"name":"Shandong Province Medical Science and Technology Development Project of China","award":["2011QZ003"],"award-info":[{"award-number":["2011QZ003"]}]},{"name":"Shandong Province Science and Technology Development Project of China","award":["2011YD18069"],"award-info":[{"award-number":["2011YD18069"]}]},{"name":"Binzhou City Science and Technology Development Project of Shandong Province, China","award":["2011ZC0914"],"award-info":[{"award-number":["2011ZC0914"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Th17\/Treg imbalance is involved in several autoimmune, inflammatory and allergic reactions. Nevertheless, the possible contribution of Th17\/Treg imbalance in atopic dermatitis (\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ) remains unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To explore the possible role of Th17\/Treg imbalance in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Th17 and Treg cells percentage in peripheral blood mononuclear cells (\n                      <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>\n                      s) and skin specimens, specific transcription factor retinoic acid\u2010related orphan receptor (ROR)\u03b3t and Foxp3\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      levels in\n                      <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>\n                      s, as well as Th17\u2010 and Treg\u2010related cytokines\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      levels in\n                      <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>\n                      s, serum concentrations, and expression levels in\n                      <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>\n                      s culture supernatant after recombinant Dermatophagoides pteronyssinus antigen stimulation were detected in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      patients. Controls included patients with psoriasis, allergic contact dermatitis (\n                      <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>\n                      ) and healthy donors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Th17 cells percentage, ROR\u03b3t, IL\u201017 and IL\u201023 levels in peripheral circulation of\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      patients were significantly higher than those in\n                      <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>\n                      patients and healthy controls, but lower than those of psoriasis patients. Treg cells percentage, Foxp3 and TGF\u2010\u03b2\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      levels were reduced in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      patients compared with healthy controls, while there were no significant differences among\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>\n                      and psoriasis patients. Th17 cells percentage, IL\u201017 and IL\u201023 levels were increased, while Treg cells percentage and TGF\u2010\u03b2 level were decreased in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      lesion and\n                      <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>\n                      s culture supernatant respectively. There was a negative association between Th17 and Treg cells percentage in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      patients.\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      severity score positively correlated with Th17 cells percentage and Th17\/Treg ratio, while negatively correlated with Treg cells percentage. Serum IgE levels positively correlated with Th17\/Treg ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      , there exists an immune imbalance in Th17 and Treg cells, which may contribute to its pathogenesis and development.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.12288","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T06:53:14Z","timestamp":1383807194000},"page":"1079-1086","source":"Crossref","is-referenced-by-count":79,"title":["The Imbalance of Th17 cells and\n                    <scp>CD<\/scp>\n                    4\n                    <sup>+<\/sup>\n                    <scp>CD<\/scp>\n                    25\n                    <sup>high<\/sup>\n                    Foxp3\n                    <sup>+<\/sup>\n                    Treg cells in patients with atopic dermatitis"],"prefix":"10.1111","volume":"28","author":[{"given":"L.","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Dermatology Binzhou Medical University Hospital Binzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010B.","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Binzhou Medical University Hospital Binzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.\u2010H.","family":"Guan","sequence":"additional","affiliation":[{"name":"State Key Department of Dermatology Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010M.","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Binzhou Medical University 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