{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:17:05Z","timestamp":1789208225099,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T00:00:00Z","timestamp":1384560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003549","name":"OTKA","doi-asserted-by":"crossref","award":["K81847"],"award-info":[{"award-number":["K81847"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003549","name":"OTKA","doi-asserted-by":"crossref","award":["PD101557"],"award-info":[{"award-number":["PD101557"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]},{"name":"T\u00c1MOP"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Factor XIII<\/jats:styled-content> subunit A (FXIII<\/jats:styled-content>\u2010A) is used as a diagnostic marker in a wide range of dermatological diseases ranging from inflammatory lesions to malignancies, although neither the cell types responsible for its expression nor the mechanism(s) resulting in its local accumulation in pathological conditions have been characterized.<\/jats:p><\/jats:sec>Objective<\/jats:title>In this study, we aimed to gain information on the cells showing an immunohistochemical reaction for FXIII<\/jats:styled-content>\u2010A and answer the question whether macrophages and\/or dendritic cells are labelled for FXIII<\/jats:styled-content>\u2010A.<\/jats:p><\/jats:sec>Methods<\/jats:title>We carried out our studies on samples of granuloma annulare (GA<\/jats:styled-content>) and necrobiosis lipoidica (NL<\/jats:styled-content>), the prime examples for granulomatous skin lesions with a non\u2010infectious background in which extracellular matrix remodelling is a key feature without any sign of malignant transformation. We used markers for macrophages and dendritic cells in combination with the detection of FXIII<\/jats:styled-content>\u2010A in double labelling immunohistochemical reactions.<\/jats:p><\/jats:sec>Results<\/jats:title>We demonstrated that FXIII<\/jats:styled-content>\u2010A positivity clearly distinguishes macrophages (CD<\/jats:styled-content>163+\/FXIII<\/jats:styled-content>\u2010A+) from dendritic cells (CD<\/jats:styled-content>11c+\/FXIII<\/jats:styled-content>\u2010A\u2212) not only in the normal dermis as previously described by Zaba et\u00a0al<\/jats:italic>. (J Clin Invest<\/jats:italic> 2007; 117:<\/jats:bold> 2517\u20132525) but also in the pathological conditions of GA<\/jats:styled-content> and NL<\/jats:styled-content>. Detecting the expression of DC<\/jats:styled-content>\u2010SIGN<\/jats:styled-content>\/CD<\/jats:styled-content>209 and mannose receptor molecules on FXIII<\/jats:styled-content>\u2010A+ macrophages we confirmed that FXIII<\/jats:styled-content>\u2010A is expressed in the alternatively activated macrophages. However, while DC<\/jats:styled-content>\u2010SIGN<\/jats:styled-content>\/CD<\/jats:styled-content>209 was invariably expressed on FXIII<\/jats:styled-content>\u2010A+ cells both in normal and pathological conditions of GA<\/jats:styled-content>\/NL<\/jats:styled-content> (98.7% vs. 93.5\/96%), mannose receptor was only partially coexpressed with FXIII<\/jats:styled-content>\u2010A (94.8% vs. 74.7\/52.2%), suggesting that FXIII<\/jats:styled-content>\u2010A+ macrophages do not represent a homogenous population.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>FXIII\u2010A selectively marks macrophages and distinguishes them from dendritic cells. The presence of FXIII<\/jats:styled-content>\u2010A is not a disease\u2010specific marker but indicates a possible common mechanism of macrophage activation in various dermatological diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12290","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T10:01:13Z","timestamp":1384596073000},"page":"1087-1096","source":"Crossref","is-referenced-by-count":14,"title":["Detection of factor XIII<\/scp>\u2010A is a valuable tool for distinguishing dendritic cells and tissue macrophages in granuloma annulare and necrobiosis lipoidica"],"prefix":"10.1111","volume":"28","author":[{"given":"D.","family":"T\u00f6r\u00f6csik","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Medical and Health Science Centre University of Debrecen Debrecen 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Medical and Health Science Centre University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Paragh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Medical and Health Science Centre University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"P\u00e9ter","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Medical and Health Science Centre University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bal\u00e1zs","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Faculty of Public Health Medical and Health Science Centre University of Debrecen Debrecen 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