{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T01:18:04Z","timestamp":1784423884894,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Dermatology"},{"name":"Adknoma Health Research"},{"name":"Bayer-Intendis"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical corticosteroids (TC) consistently show effectiveness against itch, a paradigmatic symptom, in various eczemas. Rapid itch relief is a therapeutic goal. The early response of itch to TC has not been adequately studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the effect on itch of a TC, methylprednisolone aceponate 0.1% ointment (MPA), in induced eczema in volunteers sensitized to nickel sulphate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen volunteers with a late positive patch\u2010test reaction to nickel sulphate entered the study. Eczema was treated once daily with \u00bc fingertip unit of MPA for 5\u00a0days. Pruritus intensity was assessed with a 10\u00a0cm visual analogue scale (VAS). Mean time to itch relief (T<jats:sub>R<\/jats:sub>) defined as the time to reach a 30% decrease in the highest VAS value recorded was assessed, as well as T<jats:sub>R\u2010baseline,<\/jats:sub> colorimetry and planimetric morphometry of the reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean T<jats:sub>R<\/jats:sub> was 1.0\u00a0days [standard deviation (SD)\u00a0=\u00a01.1] and mean T<jats:sub>R<\/jats:sub>\u2010<jats:sub>baseline<\/jats:sub> was 1.6\u00a0days (SD\u00a0=\u00a01.4). Five volunteers reached 100% decrease from itch baseline\u2010VAS in 2.0\u00a0\u00b1\u00a01.2\u00a0days, whereas a 75% decrease was obtained in 1.7\u00a0\u00b1\u00a01.6\u00a0days by 16 volunteers. A clinical improvement of patch\u2010test reaction was apparent at day 11, although erythema was still present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We present a valid model to assess the efficacy and speed of action of TC treatment to alleviate pruritus and the signs of eczema. The fast effect of MPA against pruritus supports the appropriateness of treating allergic contact eczema with TC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12292","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T09:36:36Z","timestamp":1383557796000},"page":"1356-1362","source":"Crossref","is-referenced-by-count":14,"title":["Fast itch relief in an experimental model for methylprednisolone aceponate topical corticosteroid activity, based on allergic contact eczema to nickel sulphate"],"prefix":"10.1111","volume":"28","author":[{"given":"L.","family":"Curto","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital del Mar Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ll.","family":"Carnero","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"L\u00f3pez\u2010Aventin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Traveria","sequence":"additional","affiliation":[{"name":"Adknoma Health Research Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Roura","sequence":"additional","affiliation":[{"name":"Adknoma Health Research Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar Universitat Aut\u00f2noma Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(01)00173-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.11.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01220.x"},{"key":"e_1_2_7_5_1","first-page":"36","article-title":"Allergic contact dermatitis","volume":"3","author":"Nelson JL","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_6_1","first-page":"228","article-title":"The biostatiscal significance of panel size in patch testing","volume":"5","author":"Jackson EM","year":"1994","journal-title":"Am J Contact Dermat"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0676"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08941.x"},{"key":"e_1_2_7_9_1","first-page":"471","article-title":"The influence of itching on atopic dermatitis patients\u2019 well\u2010being","volume":"87","author":"Reich A","year":"2007","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05743.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07430.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2340\/00015555-0432","article-title":"Itch intensity evaluated in the German atopic dermatitis intervention study (GADIS): correlation with quality of life, coping behavior and SCORAD severity in 823 children","volume":"88","author":"Weisshaar E","year":"2008","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04019.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02480-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01460.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2310\/6620.2010.09057","article-title":"Quality of life and contact dermatitis: a disease \u2013specific questionnaire","volume":"21","author":"Ayala F","year":"2010","journal-title":"Dermatitis"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3310\/hta4370","article-title":"Systematic review of treatments for atopic eczema","volume":"4","author":"Hoare C","year":"2000","journal-title":"Health Technol Assess"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7340.768"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03789.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2005.00754.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01269.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00706.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.04.008"},{"key":"e_1_2_7_24_1","first-page":"48","article-title":"Efficacy and onset of action of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% lotion for the management of pruritus. Results of a pilot study","volume":"4","author":"Kircik LH","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1246"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1265"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1446"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2003.480208.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2007.06007"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01800.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12292","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:25:46Z","timestamp":1695565546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,4]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/jdv.12292"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12292","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,4]]}}}