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It classically presents with cutaneous patches and plaques and can progress to tumours on the skin with lymph node, blood and visceral involvement. While most patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> have a relatively benign disease course, a subset of patients will develop progressive disease that is often fatal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to identify genetic markers in early <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> limited to the skin (stages <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IIA<\/jats:styled-content>) that distinguish those patients who will have progressive disease from those who will not, so that early appropriate treatment may be instituted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study includes 18 patients who were diagnosed with early stage <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> at the time of biopsy and had follow\u2010up to determine which patients developed progressive disease. <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> was extracted from skin biopsy specimens and analysed for expression of <jats:italic><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u03b3,<\/jats:italic> Interleukin (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013, <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">MICB<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PLS<\/jats:styled-content>3<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4<\/jats:italic> by quantitative real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results\/Conclusions<\/jats:title><jats:p>Reduced expression of <jats:italic><jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>4<\/jats:italic> and increased expression of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<\/jats:italic> relative to <jats:italic><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3<\/jats:italic> expression levels were significantly associated with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> progression. Further studies will be needed to fully assess the usefulness of these genetic markers to predict disease progression and guide treatment options in patients diagnosed with early <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12299","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T11:23:17Z","timestamp":1383218597000},"page":"1431-1435","source":"Crossref","is-referenced-by-count":32,"title":["Genetic markers associated with progression in early mycosis fungoides"],"prefix":"10.1111","volume":"28","author":[{"given":"V.E.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Medicine\/Dermatology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.C.","family":"Vonderheid","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Johns Hopkins Medical Institution 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