{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:40:53Z","timestamp":1776080453407,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anti\u2010<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>5 (Melanoma differentiation\u2010associated gene 5) positive dermatomyositis is a new variant of clinically amyopathic dermatomyositis that presents with characteristic mucocutaneous findings and is associated with a higher risk of developing rapidly progressive interstitial lung disease. Because its presentation differs from that of classical dermatomyositis, this entity can be a diagnostic challenge for the clinician.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods &amp; Results<\/jats:title><jats:p>We present the case of a 55\u2010year\u2010old male with a 7\u2010month history of chill sensation, constitutional symptoms and polyarthralgia. Within 3 months, the patient developed progressive heart failure with dyspnoea and orthopnoea, together with characteristic cutaneous lesions. Skin biopsies demonstrated thrombosis of small and medium\u2010sized arteries in the reticular dermis, together with an evolved lobular panniculitis and prominent mucin deposits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinicians should be aware of the characteristic clinical and histopathologic presentation of this variant of dermatomyositis to establish an early diagnosis. Further evidence is needed to clarify the risk of cardiac involvement in this subset of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12300","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T03:08:38Z","timestamp":1383102518000},"page":"1097-1102","source":"Crossref","is-referenced-by-count":24,"title":["Anti\u2010<scp>MDA<\/scp>5 positive clinically amyopathic dermatomyositis presenting with severe cardiomyopathy"],"prefix":"10.1111","volume":"28","author":[{"given":"I.","family":"Pau\u2010Charles","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Intensive Care Unit Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ortiz\u2010Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Lucero","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Intensive Care Unit Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Garcia\u2010Herrera","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Autoimmune Diseases Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Intensive Care Unit Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Intensive Care Unit Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Intensive Care Unit Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Casciola\u2010Rosen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"J.M.","family":"Mascar\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Cl\u00ednic. Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90132-X"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05157-0"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.041"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01144.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199211000-00001"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep078"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21023"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.016"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24621"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182606f0b"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-012-0663-4"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21728"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker518"},{"key":"e_1_2_4_15_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1468-3083.2006.02012.x","article-title":"Nail changes in connective tissue diseases: do nail changes provide clues for the diagnosis?","volume":"21","author":"Tunc S","year":"2007","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90408-8"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22026"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101220"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12300","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:49:39Z","timestamp":1716079779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,29]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/jdv.12300"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12300","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,29]]}}}