{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:37:28Z","timestamp":1791877048194,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T00:00:00Z","timestamp":1385164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Seborrheic dermatitis (SD) is a chronic inflammatory skin disease that shares some features with psoriasis. Previous reports have demonstrated an association between hypertension and psoriasis. Chronic skin inflammation may plays a role in the aetiology of hypertension in both disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between SD and hypertension in an adult large population sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was carried out by utilizing the database of Clalit Health Services, a healthcare provider organization for over 4 million enrollees in Israel. All adult patients previously diagnosed with SD were compared with a sample of enrollees without SD regarding the prevalence of hypertension. Patients without SD were frequency matched to SD patients regarding age and sex. Data on other health\u2010related lifestyles and comorbidities were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included all 9255 patients with SD and 9246 age\u2010 and sex\u2010matched patients without SD. The prevalence of hypertension was significantly higher in patients with SD (27.1% vs. 24.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, OR\u00a0=\u00a01.13, 95% CI: 1.05\u20131.21). A multivariate logistic regression model demonstrated that SD was significantly associated with hypertension after controlling for confounders, including age, sex, socioeconomic status, smoking, diabetes and obesity (multivariate OR\u00a0=\u00a01.23, 95% CI: 1.12\u20131.35, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, an association between SD and hypertension was demonstrated in adults. Many factors can be advocated to explain this association. Genetic predisposition, psychological conditions, lipid abnormalities and chronic inflammation of the skin with a change in cytokine balance should be explored as potential mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12310","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T10:24:35Z","timestamp":1385375075000},"page":"1450-1455","source":"Crossref","is-referenced-by-count":32,"title":["Seborrheic dermatitis and hypertension in adults: a cross\u2010sectional study"],"prefix":"10.1111","volume":"28","author":[{"given":"D.","family":"Linder","sequence":"first","affiliation":[{"name":"Dermatology Unit Padua University Hospital Padua Italy"},{"name":"University Clinic for Medical Psychology and Psychotherapy Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dreiher","sequence":"additional","affiliation":[{"name":"Hospital Division Clalit Health Services Tel Aviv Israel"},{"name":"Siaal Research Center for Family Medicine and Primary Care Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zampetti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universit\u00e0 Cattolica del \u201cSacro Cuore\u201d Rome Italy"},{"name":"Department of Dermatology Royal Free Hospital NHS London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sampogna","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata IDI IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Siaal Research Center for Family Medicine and Primary Care Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"},{"name":"Chief Physician's Office Clalit Health 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