{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:27:42Z","timestamp":1790112462030,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"F\u0131rat University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aphthae constitute one of the major signs in Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) and recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>). No scientific study has yet explored the relationship of hepcidins, which have antimicrobial effects, with<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study, we aimed to evaluate by immunohistochemistry whether hepcidin is synthesized by the salivary glands and to measure levels of prohepcidin and hepcidin (an antibacterial peptide) in the serum and saliva of patients with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 25<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>patients and 30<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>patients, as well as a control group comprising 25 healthy individuals. Serum and saliva samples were collected at the same time from all subjects. Levels of prohepcidin and hepcidin were measured by<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. The presence of hepcidin in salivary glands was assessed by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hepcidin was localized in the striated ducts of the sublingual and parotid glands. Saliva prohepcidin and hepcidin levels were correlated with blood levels. Saliva prohepcidin levels were found to be lower in<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>patients than in<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>patients and healthy controls (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001 and<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007 respectively). In addition,<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>patients had lower saliva hepcidin levels than did the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The lower serum and saliva prohepcidin and hepcidin concentrations found in<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>patients indicate that hepcidin may be involved in the aetiopathogenesis of these diseases. Because it can be obtained non\u2010invasively and easily, saliva may provide a useful alternative to serum in quantifying prohepcidin and hepcidin concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12326","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T07:44:49Z","timestamp":1387266289000},"page":"1500-1506","source":"Crossref","is-referenced-by-count":13,"title":["Does hepcidin play a role in the pathogenesis of aphthae in Beh\u00e7et's disease and recurrent aphthous stomatitis?"],"prefix":"10.1111","volume":"28","author":[{"given":"D.","family":"Cicek","sequence":"first","affiliation":[{"name":"Department of Dermatology Firat University Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.","family":"Da\u011fl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pathology Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group) Firat University Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Baskaya Dogan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Education and Research Hospital Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.B.","family":"Dertlio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Firat University Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"U\u00e7ak","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dicle University Diyarbakir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Dermatology Education and Research Hospital Elazig Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.04.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.05841.x"},{"key":"e_1_2_6_4_1","first-page":"489","article-title":"The role of streptococcal hypersensitivity in the pathogenesis of Beh\u00e7et's Disease","volume":"18","author":"Kaneko F","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2007.48.4.573"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11705"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008922200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.06.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2010.08.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2009.06.012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3235"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2009.1.207"},{"key":"e_1_2_6_13_1","first-page":"121","article-title":"Beh\u00e7et's disease: a dentist's overview","volume":"26","author":"Mumcu G","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.996"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01143.x"},{"key":"e_1_2_6_16_1","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","author":"International Study Group for Beh\u00e7et's Disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_6_17_1","first-page":"607921","article-title":"Diagnosis\/Classification Criteria for Behcet's Disease","volume":"2012","author":"Davatchi F","year":"2012","journal-title":"Patholog Res Int"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01134.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0697"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i17.2129"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-009-0073-x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-34-1-39"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00251.x"},{"key":"e_1_2_6_25_1","first-page":"6","article-title":"Beh\u00e7et's Disease Research Committee of Japan. 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