{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:19:31Z","timestamp":1791386371590,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic inflammation was found to play an important role in the development of cardiovascular risk factors. Homocysteine (Hcy) and fibrinogen have been identified as a major independent risk factor for cardiovascular disease. Lichen planus is assumed to be closely related to dyslipidaemia. Several cytokines involved in lichen planus pathogenesis, could explain its association with dyslipidaemia. Also chronic inflammation with lichen planus has been suggested as a component of the metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to detect a panel of cardiovascular risk factors in patients of lichen planus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>This study was done on 40 patients of lichen planus and 40 healthy controls. All patients and controls were subjected to clinical examination. Serum levels of homocysteine, fibrinogen and high\u2010sensitive C\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) were measured by enzyme\u2010linked immunosorbent assay technique (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>). Metabolic syndrome parameters including anthropometric measures, lipid profiles, blood sugar and blood pressure were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with lichen planus showed significant association with metabolic syndrome parameters than controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Serum homocysteine, fibrinogen and hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> were significantly higher in lichen planus patients than controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Serum homocysteine correlated with both serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and serum fibrinogen. However, there was no correlation between serum levels of homocysteine and fibrinogen with any metabolic syndrome criteria and related disorders except for a negative correlation of fibrinogen with high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the present work, patients with lichen planus were found to have higher makers of both metabolic and cardiovascular risk factors in relation to controls most probably due to long standing inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12329","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T11:34:35Z","timestamp":1386848075000},"page":"1507-1513","source":"Crossref","is-referenced-by-count":35,"title":["Homocysteine and other cardiovascular risk factors in patients with lichen planus"],"prefix":"10.1111","volume":"28","author":[{"given":"N.","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Samir","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Megahed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology National research center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Farid","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63649-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.108"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg129"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2007.033"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.70667"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2143\/AC.61.4.2017305"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-005-0033-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-010-9200-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/clinchem\/47.3.403","article-title":"High\u2010sensitivity C\u2010reactive protein: a novel and promising marker of coronary heart disease","volume":"47","author":"Rifai N","year":"2001","journal-title":"Clin Chem"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69251-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.8533"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319707303443"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.633750"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.49.1.31"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07503.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300327"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701247930"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300423"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.251"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00013-8"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.6.1368"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503093321003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.12.025"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1066020"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.22.2685"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.03983.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09235.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/806102"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0367"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3597(07)80025-1"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12329","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:33:53Z","timestamp":1695504833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,12]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/jdv.12329"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12329","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,12]]}}}