{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:58:47Z","timestamp":1780491527283,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Edvard Welander and Finsen foundations"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Loss\u2010of\u2010function mutations in FLG<\/jats:styled-content> (encoding filaggrin) are a predisposing factor for atopic dermatitis (AD<\/jats:styled-content>) and cause ichthyosis vulgaris (IV<\/jats:styled-content>). Patients with AD<\/jats:styled-content> and IV<\/jats:styled-content> display impaired skin barrier and dry skin, and altered epidermal expression of genes in pro\u2010inflammatory and lipid metabolic pathways are often evident.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To evaluate the effect of three different moisturizers on skin barrier function and epidermal gene expression in patients with AD<\/jats:styled-content>\/IV<\/jats:styled-content> in relation to FLG<\/jats:styled-content> mutation status.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients (n<\/jats:italic>\u00a0=\u00a043) were classified according to their FLG<\/jats:styled-content> status: AD<\/jats:styled-content> with FLG<\/jats:styled-content>+\/+ (n<\/jats:italic>\u00a0=\u00a014), AD<\/jats:styled-content> with FLG<\/jats:styled-content>+\/\u2212 (n<\/jats:italic>\u00a0=\u00a014), and AD<\/jats:styled-content>\/IV<\/jats:styled-content> with FLG<\/jats:styled-content>\u2212\/\u2212 (n<\/jats:italic>\u00a0=\u00a015). Dryness score and transepidermal water loss (TEWL<\/jats:styled-content>) were monitored on volar forearms, and punch biopsies were taken for analysis of gene expression. Measurements were repeated after 4\u00a0weeks of treatment with either of two moisturizers on each forearm.<\/jats:p><\/jats:sec>Results<\/jats:title>Treatment with any of the three moisturizers significantly reduced dryness score and TEWL in the group as a whole. FLG\u2212\/\u2212 patients displayed the largest reduction in dryness score. Only minute changes occurred in the mRNA<\/jats:styled-content> expression of 15 selected epidermal genes.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Moisturizing treatment improves dry skin and certain aspects of abnormal skin barrier function, especially in patients with AD<\/jats:styled-content>\/IV<\/jats:styled-content> and dual FLG<\/jats:styled-content> mutations, but does not normalize the epidermal gene expression profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12333","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T11:54:43Z","timestamp":1386849283000},"page":"174-177","source":"Crossref","is-referenced-by-count":18,"title":["Moisturizing treatment of patients with atopic dermatitis and ichthyosis vulgaris improves dry skin, but has a modest effect on gene expression regardless of FLG<\/scp> genotype"],"prefix":"10.1111","volume":"29","author":[{"given":"T.","family":"Hoppe","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Dermatology and Venereology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.G.","family":"Winge","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Dermatology and Venereology Unit, and Center for Molecular Medicine Karolinska Institutet Karolinska University Hospital Solna Stockholm Sweden"},{"name":"Department of Molecular Medicine & Surgery and Center for Molecular Medicine Karolinska Institutet Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Dermatology and Venereology Unit, and Center for Molecular Medicine Karolinska Institutet Karolinska University Hospital Solna Stockholm Sweden"},{"name":"Department of Molecular Medicine & Surgery and Center for Molecular Medicine Karolinska Institutet Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nordenskj\u00f6ld","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine & Surgery and Center for Molecular Medicine Karolinska Institutet Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vahlquist","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Dermatology and Venereology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"T\u00f6rm\u00e4","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Dermatology and Venereology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Berne","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Dermatology and Venereology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07685.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10979.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0958-2"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0906-6"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1743"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.033969"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.033969"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028254"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245677"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304110-00005"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09142.x"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004017"}],"container-title":["Journal 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